Dexamethasone CPG

Question 1

Dexamethasone - Presentation

Answer 1

8 mg in 2 mL glass vial

Question 2

Dexamethasone - Pharmacology

Answer 2

A corticosteroid secreted by the adrenal cortex

Actions:

• Relieves inflammatory reactions
• Provides immunosuppression

Question 3

Dexamethasone - Metabolism

Answer 3

By the liver and other tissues; excreted predominantly by the kidneys

Question 4

Dexamethasone - Primary emergency indications

Answer 4

1. Bronchospasm associated with acute respiratory distress not responsive to nebulised Salbutamol
2. Moderate - severe croup
3. Acute exacerbation of COPD

Question 5

Dexamethasone - Contraindications

Answer 5

1. Known hypersensitivity

Question 6

Dexamethasone - Precautions

Answer 6

1. Solutions which are not clear or are contaminated should be discarded

Question 7

Dexamethasone - Route of administration

Answer 7

IV (administered over 1-3min)

Oral

Question 8

Dexamethasone - Side effects

Answer 8

Nil of significance in above indication

Question 9

Dexamethasone - Special notes

Answer 9

Does not contain an antimicrobial agent, therefore use solution immediately and discard any residue

IV effects:

Onset: 30-60min

Peak: 2hours

Duration: 36-72hours