What is the cause of Type 1 Diabetes (T1DM)?
Autoimmune destruction of beta cells → no insulin.
What is the typical onset age for Type 1 Diabetes (T1DM)?
Sudden (often <30 yrs).
What are the symptoms of Type 1 Diabetes (T1DM)?
3 P’s (polyuria, polydipsia, polyphagia), weight loss, fatigue.
What are the risk factors for Type 1 Diabetes (T1DM)?
Genetics, autoimmune conditions.
What is the emergency condition associated with Type 1 Diabetes (T1DM)?
DKA (diabetic ketoacidosis).
What is the cause of Type 2 Diabetes (T2DM)?
Insulin resistance + impaired secretion.
What is the typical onset age for Type 2 Diabetes (T2DM)?
Gradual (common >40 yrs, now younger w/ obesity).
What are the symptoms of Type 2 Diabetes (T2DM)?
3 P’s, fatigue, weight gain.
What are the risk factors for Type 2 Diabetes (T2DM)?
Age, obesity, sedentary lifestyle, metabolic syndrome.
What is the emergency condition associated with Type 2 Diabetes (T2DM)?
HHS (hyperosmolar hyperglycemic syndrome).
What is hypoglycemia?
BG <70.
What are the symptoms of hypoglycemia?
Sweating, tremors, irritability, hunger, tachycardia, confusion, seizures, coma.
What causes hypoglycemia?
Too much insulin, not enough food, excess exercise.
What is the treatment for hypoglycemia?
15 g fast carbs (juice, glucose tabs, candy). Recheck in 15 min. If unconscious → glucagon IM or D50 IV.
What is hyperglycemia?
Fasting BG >100–126 or random >200.
What are the symptoms of hyperglycemia?
Polyuria, polydipsia, blurred vision, fatigue.
What causes hyperglycemia?
Illness, poor med adherence, stress, diet.
What is DKA in Type 1 Diabetes?
No insulin → fat breakdown → ketones → acidosis.
What are the symptoms of DKA?
High BG, ketones in urine, N/V, abdominal pain, fruity breath, Kussmaul respirations, confusion.
What is the treatment for DKA?
Needs IV insulin + fluids.
What is HHS in Type 2 Diabetes?
Extreme hyperglycemia + dehydration (no ketones).
What are the symptoms of HHS?
BG >600, dry mouth, thirst, confusion, seizures, coma.
What is the treatment for HHS?
IV fluids, insulin, electrolyte correction.
What is insulin resistance?
Body cells don’t respond to insulin.