Antidiarrheal drugs (3 groups)
Opioids
Locally acting drugs
5-HT3 antagonist
Opioids for diarrhea (2 drugs)
Diphenoxylate
Loperamide
Most efficacious antidiarrheal agents (1 group)
Opioids
Locally acting antidiarrheal drugs (3 drugs)
Psyllium hydrophilic mucilloid
Calcium polycarbophil
Bismuth subsalicylate
Bismuth subsalicylate - indications
Infectious diarrhea
5-HT3 receptor antagonist used for diarrhea
Alosetron
Alosetron - MOA in diarrhea
Inhibits motility by motility by blocking 5-HT3 receptors, which inhibits release of ACh from intrinsic myenteric neurons.
Alosetron - indications
IBS with diarrhea (alternative treatment)
Alosetron - adverse effect
Ischemic colitis