Diazepam

Question 1

Diazepam class

Answer 1

Benzodiazepine

Question 2

Diazepam MOA

Answer 2

Binds to GABA(A) receptors, increases Cl permeability leading to hyperpolarization & inhibition of neuronal firing

Question 3

Diazepam dosage

Answer 3

Ind: 0.5 - 1 mg/kg

Seizure: 0.1 mg/kg q 10-15 min (max 30 mg)

Question 4

Diazepam characteristics

Answer 4

O: 1-5 min

P: 5-15 min

D: 15 min to an hour

Question 5

Diazepam E/M

Answer 5

Hepatic microsomal enzymes using oxidative pathway of N-demethylation

Question 6

Diazepam considerations

Answer 6

Reduces requirements for VA;
Elderly have decreased clearance & dosage requirements;
May cause neonatal hypothermia