DIC

Question 1

Pathogenesis of DIC:

Answer 1

release of procoagulants -> widespread abnormal clotting -> consumption of platelets and clotting factors -> susceptibility to bleeding

Question 2

microangiopathic hemolysis

Answer 2

microthrombi formation causes mechanical shearing of RBCs

Question 3

DIC presentation

Answer 3

bleeding from all orifices
dermal purpura
multi organ failure
shock

Question 4

DIC: decreased platelet count, increased bleeding time

Answer 4

due to consumption of platelets in microthrombi

Question 5

increased PT and PTT, decreased fibrogen

Answer 5

due to consumptive use of clotting factors

Question 6

DIC associated pathology:

Answer 6

shistocytes
nutmeg liver
shock liver
dermal purpura

Question 7

Treatment DIC:

Answer 7

supportive fluids, blood products, pressors
treat underlying disorder