Diffuse Alveolar Damage

Question 1

What is DAD?

Answer 1

• Your father

- Nah jk it is the histological responses of interstitial lung disease and other conditions

Question 2

What three conditions is acute DAD seen?

Answer 2

• ARDS
• Acute interstitial pneumonia
• Hyaline membrane disease

Question 3

What are the 2 stages of DAD?

Answer 3

• Exudative stage

- Proliferative stage

Question 4

What happens in the exudative stage?

Answer 4

• Oedema

- Hyaline membranes

Question 5

Describe the oedema formed in the exudative stage?

Answer 5

• Similar to pulmonary oedema in that the alveoli become flooded with transudate

Question 6

What does the hyaline membrane stage consist of?

Answer 6

• Fibrous structures laid down

- Stop oxygen being absorbed

Question 7

What happens during the proliferative stage?

Answer 7

• Interstitial inflammation

- Interstitial fibrosis

Question 8

What are the histological features of DAD?

Answer 8

• Protein rich oedema
• Fibrin
• Hyaline membranes
• Epithelial and fibroblast proliferation
• Scarring

Question 9

What are the causes of DAD?

Answer 9

Many Causes

• Idiopathic
• Chemical injury
• Circulatory shock
• Drugs
• Infection
• Autoimmune