Diffuse Large B-Cell

Question 1

What is diffuse large b cell lymphoma?

Answer 1

Aggressive mature b cell lymphoma that accounts for 30% of all NHL

Question 2

Who does it affect?

Answer 2

Elderly people

Question 3

What is seen on morphology?

Answer 3

Sheets of large b cells are seen in or after the germinal centre
If they are found within the germinal centre then this is a better prognostic phenotype associated with ongoing Ig mutations, bcl2, c-rel amplification

Question 4

What are the cytogenetic abnormalities?

Answer 4

P53 is affected this has the worst prognosis