Digoxin toxicity
Arrythmias ๐ Diarrhoea N+V Skin reactions Vision disorders ๐๏ธ -yellow -blurred vision
Toxicity range
1.5 - 3microgram/L
Monitoring
Bloods 6 hours after dose
Dig plasma concentration
Serum electrolyte
Ca- high = toxicity
Mg- low = toxicity
K-Low = toxicity. hypOkalaemia- toxicity
Renal function - reduce dose in impairment
Heart rateInteractions
St John's wort โdig conc Diuretics - lead to hypokalaemia = toxicity NSAIDs ACE inhibitors Beta blockers ๐ค block Antacids - 2 hours apart