Diseases

Question 1

Loss of what protein leads to epithelial-mesenchymal transition (EMT; metastasis) during cancer progression?

Answer 1

• E-cadherin

Question 2

Claudin 16 mutation:

Answer 2

• tight junction mutation
• autosomal-recessive renal disorder:
  
  • hypomagnesemia
  • hypercalciuria
  • nephrocalcinosis

Question 3

P-cadherin mutation:

Answer 3

• belt desmosome mutation
• early hair loss
• progressive degeneration of the central retina

Question 4

Defects in what types of junctions will cause blistering diseases?

Answer 4

• hemidesmosomes
• spot desmosomes

DUE TO AN AUTOIMMUNE DISEASE

Question 5

Pemphigus:

Answer 5

• autoimmune disease with antibodies against desmoglein 1
• defect in spot desmosomes
• chronic blistering

Question 6

Pemphigoid:

Answer 6

• autoimmune disease with antibodies against BPAG 1 and 2
• defect in hemidesmosomes
• chronic blistering