Diuretics

Question 1

Name the 3 classes of diuretics

Answer 1

Loop diuretics, thiazide diuretics and potassium sparing diuretics.

Question 2

What is the MOA of loop diuretics?

Answer 2

Inhibits Na+/K+/2CI- cotransporter in the thick ascending loop of Henle

Question 3

What is the MOA of thiazide diuretics?

Answer 3

inhibits the sodium chloride transporter in the early distal convoluted tubule

Question 3

What is two adverse effects of diuretics?

Answer 3

hyperkalaemia and hypernatraemia

Question 4

What should you monitor with diuretics? (3)

Answer 4

Monitor serum electrolytes, potassium and renal function baseline.

Question 5

What is the difference in potency of loop and thiazide diuretics?

Answer 5

Loop- potent (20-25% of sodium is reabsorbed)
Thiazide- not potent (5-10% of sodium is reabsorbed)