1
Q
Loop diuretic MOA
A
Blocks NKCC2 channels in thick ascending loop of Henle
Prevent reabsorption of 25% Na+
Reduces renin secretion
2
Q
Loop diuretic examples
A
Furosemide
Bumetanide
Indapamide
3
Q
Loop diuretics SE
A
Ototoxicity
Metabolic alkalosis
⬇️K+, Mg2+, PO43-
⬆️Na+
Acidification of urine
4
Q
Thiazide diuretic examples
A
Bendroflumethiazide
Metolozone (thiazide-like)
5
Q
Thiazide diuretics MOA
A
Block NaCl cotransporter in DCT
Prevents reabsorption of 10% Na+
6
Q
Thiazide diuretic SE
A
⬇️K+, Na+, Cl-
⬆️glucose tolerance
⬇️BP
Impotence
