Diuretics

Question 0

Major site of NaCl and NaCO3 reabsorption

Reabsorption of amino acids, glucose and numerous cations

Uric acid site of transport

Answer 0

PCT -BIBO!

Acted upon by CAI

Question 1

Site of action of diuretics

Answer 1

Carbonic anhydrase inhibitor: PCT
Loop diuretics: Thick Ascending Limb
Thiazides: DCT
Potassium-sparing diuretics: CCT (cortical CT)
Osmotic diuretics: PCT, Descending limb of loop of Henle, CD

Question 2

CAI used for glaucoma and mountain sickness

Answer 2

Acetazolamide

SimD: Dorzolamide, Brinzolamide, Dichlorphenamide, Methazolamide

Question 3

IMPORTANT SE of Acetazolamide

Answer 3

ACIDazolamide causes ACIDosis

Hyperchloremic metabolic acidosis, potassium wasting, renal calcium stones, HepEnceph on cirrhotic pxs