DOAC's

Question 1

What are 4 DOAC’s?

Answer 1

• Rivaroxiban
• Apixaban
• Dabigatran
• Edoxaban

Question 2

All DOAC’s apart from dabigatran target which clotting factor?

Answer 2

Factor Xa

Question 3

What clotting factor does dabigatran target?

Answer 3

Thrombin (IIa)

Question 4

Why use DOAC’s over warfarin?

Answer 4

• Similar recution in VTE risk
• Reduced risk of bleeding

Question 5

What is the main problem with DOAC’s?

Answer 5

Only dabigatran has an antidote and otherwise you have to wait for the drugs to be eliminated

Question 6

How long will it take a person with normal renal function to metabolise DOAC so that clotting function is normal?

Answer 6

24 hours

Question 7

How long will it take a person with reduced renal function to metabolise DOAC so that clotting function is normal?

Answer 7

48 hours