donepezil

Question 1

MoA and drug class

Answer 1

Ach-esterase inhibitor
reversible inhibitor of Ach-esterase

Question 2

dose in mild to moderate dementina in AD

Answer 2

initally 5mg OD for one month
increase if necessary to 10mg OD
to be taken at night

Question 3

what time of the day do you take it

Answer 3

bedtime

Question 4

common SE

Answer 4

• aggression, agitation
• decreased appetite
• common cold
• diarrhoea, GI disorders, nausea, vomiting
• syncope
• urinary incontinence
• muscle cramps
• hallucination

Question 5

use with caution in …. (5)

Answer 5

• asthma
• COPD
• sick sinus syndrome
• SV conduction abnormalities
• suscepibility to peptic ulcers

Question 6

interactions - increased risk of bradycardia

Answer 6

• beta blockers
• RL CCBs
• anti-arrhtyhmics e.g. dronedarone, amiodarone, fleicanide
• digoxin