Acyclovir
Acute Treatment of Herpes Zoster : 800 mg every 4 hours orally, 5 times daily for 7 to 10 days.
Genital Herpes: Treatment of Initial Genital Herpes : 200 mg every 4 hours, 5 times daily for 10 days
Salbutamol
For treatment of acute episodes of bronchospasm or prevention of asthmatic symptoms, • The usual dosage for adults and children 4 years of age and older is two inhalations repeated every 4 to 6 hours. • More frequent administration or a larger number of inhalations is not recommended. • In some patients, one inhalation every 4 hours may be sufficient. Exercise Induced Bronchospasm Prevention • The usual dosage for adults and children 4 years of age and older is two inhalations 15 to 30 minutes before exercise. • To maintain proper use of this product, it is important that the mouthpiece be washed and dried thoroughly at least once a week.
Alendronate Sodium
Treatment Of Osteoporosis In Postmenopausal Women The recommended dosage is: •one 70 mg tablet once weekly or •one bottle of 70 mg oral solution once weekly or •one 10 mg tablet once daily Prevention Of Osteoporosis In Postmenopausal Women The recommended dosage is: •one 35 mg tablet once weekly or •one 5 mg tablet once daily Treatment To Increase Bone Mass In Men With Osteoporosis The recommended dosage is: •one 70 mg tablet once weekly or •one bottle of 70 mg oral solution once weekly or •one 10 mg tablet once daily Treatment Of Glucocorticoid-Induced Osteoporosis -The recommended dosage is one 5 mg tablet once daily, except for postmenopausal women not receiving estrogen, for whom the recommended dosage is one 10 mg tablet once daily.
Amiodarone
Ventricular Arrhythmias Loading Dose (Daily) : 1 to 3 weeks , 800 to 1,600 mg Adjustment and Maintenance Dose (Daily) : ~1 month 600 to 800 mg ,usual maintenance 400 mg
Atorvastatin(Lipitor)
Hyperlipidemia And Mixed Dyslipidemia
- The recommended starting dose of LIPITOR is 10 or 20 mg once daily. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily.
- The dosage range of LIPITOR is 10 to 80 mg once daily.
Celecoxib
-Use lowest effective dose for the shortest duration consistent with treatment goals for the individual patient -These doses can be given without regard to timing of meals. Osteoarthritis • For relief of the signs and symptoms of OA the recommended oral dose is 200 mg per day administered as a single dose or as 100 mg twice daily. Rheumatoid Arthritis • For relief of the signs and symptoms of RA the recommended oral dose is 100 to 200 mg twice daily. Juvenile Rheumatoid Arthritis • For the relief of the signs and symptoms of JRA the recommended oral dose for pediatric patients (age 2 years and older) is based on weight. For patients > 10 kg to < 25 kg the recommended dose is 50 mg twice daily. • For patients > 25 kg the recommended dose is 100 mg twice daily. For patients who have difficulty swallowing capsules, the contents of a CELEBREX (celecoxib) capsule can be added to applesauce.
Clopidogrel
Acute Coronary Syndrome Plavix can be administered with or without food
- For patients with non-ST-elevation ACS (UA/NSTEMI), initiate Plavix with a single 300 mg oral loading dose and then continue at 75 mg once daily. Initiate aspirin (75-325 mg once daily) and continue in combination with Plavix
- For patients with STEMI, the recommended dose of Plavix is 75 mg once daily orally, administered in combination with aspirin (75-325 mg once daily), with or without thrombolytics. Plavix may be initiated with or without a loading dose Recent MI, Recent Stroke, Or Established Peripheral Arterial Disease
- The recommended daily dose of Plavix is 75 mg once daily orally, with or without food
Recent MI, Recent Stroke, Or Established Peripheral Arterial Disease
• The recommended daily dose of Plavix is 75 mg once daily orally, with or without food
Cyclosporin A
- The initial oral dose of Sandimmune (cyclosporine) should be given 4 to 12 hours prior to transplantation as a single dose of 15 mg/kg.
- Although a daily single dose of 14 to 18 mg/kg was used in most clinical trials, few centers continue to use the highest dose, most favoring the lower end of the scale.
- The initial single daily dose is continued postoperatively for 1 to 2 weeks and then tapered by 5% per week to a maintenance dose of 5 to 10 mg/kg/day.
Dexamethasone
For oral administration
- The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated.
- It Should Be Emphasized That Dosage Requirements Are Variable And Must Be Individualized On The Basis Of The Disease Under Treatment And The Response Of The Patient.
- In the treatment of acute exacerbations of multiple sclerosis, daily doses of 30 mg of dexamethasone for a week followed by 4 to 12 mg every other day for one month have been shown to be effective
cortisone 계 9개 및 사용량 비율
Cortisone, 25
Triamcinolone, 4
Hydrocortisone, 20
Paramethasone, 2
Prednisolone, 5
Betamethasone, 0.75
Prednisone, 5
Dexamethasone, 0.75
Methylprednisolone, 4
Diazepam
ADULTS
-Management of Anxiety Disorders and Relief of Symptoms of Anxiety
:Depending upon severity of symptoms—2 mg to 10 mg, 2 to 4 times daily
-Symptomatic Relief in Acute Alcohol Withdrawal.
: 10 mg, 3 or 4 times during the first 24 hours, reducing to 5 mg, 3 or 4 times daily as needed
digoxin
Loading Dosing Regimen in Adults and Pediatric Patients
• For adults and pediatric patients if a loading dosage is to be given, administer half the total loading dose initially, then ¼ the loading dose every 4 to 8 hours twice, with careful assessment of clinical response and toxicity before each dose.
age 5 to 10 years : oral loading dose : 20-45mcg/kg
Adults and pediatric patients over 10 years : oral loading dose : 10-15mcg/kg
Donepezil 성인 및 노인
성인 및 노인 : 본품을 1일 1회, 1회 1정(5mg 정)씩 취침전 임상적 반응을 얻기 위해 적어도 1달 동안 정상상태가 될 때까지 투여하며 1달동안 임상적 반응을 평가한 후 10mg까지 증량할 수 있다. 본품의 최대 투여량은 10mg이며 10mg이상의 임상데이타는 없다. 본품 투 여를 중단시 서서히 효과가 감소하며 갑작스러운 투 여중단에 의한 반동효과는 나타나지 않는다
Donepezil FDA
ARICEPT should be taken in the evening, just prior to retiring.
• ARICEPT can be taken with or without food.
Mild to Moderate Alzheimer’s Disease
- The dosages of ARICEPT shown to be effective in controlled clinical trials are 5 mg and 10 mg administered once per day.
- The higher dose of 10 mg did not provide a statistically significantly greater clinical benefit than 5 mg.
Moderate to Severe Alzheimer’s Disease
• ARICEPT has been shown to be effective in controlled clinical trials at doses of 10 mg and 23 mg administered once daily. Results of a controlled clinical trial in moderate to severe Alzheimer’s Disease that compared ARICEPT 23 mg once daily to 10 mg once daily suggest that a 23 mg dose of ARICEPT provided additional benefit.
Titration
- a dose of 10 mg should not be administered until patients have been on a daily dose of 5 mg for 4 to 6 weeks.
- A dose of 23 mg once daily can be administered once patients have been on a dose of 10 mg once daily for at least 3 months.
Doxazosin
DOSAGE MUST BE INDIVIDUALIZED.
BENIGN PROSTATIC HYPERPLASIA 1–8 mg once daily.
HYPERTENSION 1–16 mg once daily.
• Increases in dose beyond 4 mg increase the likelihood of excessive postural effects, including syncope, postural dizziness/vertigo and postural hypotension. At a titrated dose of 16 mg once daily, the frequency of postural effects is about 12% compared to 3% for placebo.
Finasteride
- PROSCAR may be administered with or without meals.
- Monotherapy
- The recommended dose of PROSCAR is one tablet (5 mg) taken once a day.
Alopeica
- PROPECIA may be administered with or without meals.
- The recommended dose of PROPECIA is one tablet (1 mg) taken once daily.
- In general, daily use for three months or more is necessary before benefit is observed. Continued use is recommended to sustain benefit, which should be re-evaluated periodically. Withdrawal of treatment leads to reversal of effect within 12 months.
Fluoxetin
Major Depressive Disorder
- Initial Treatment
- Adult — Initiate PROZAC 20 mg/day orally in the morning. Consider a dose increase after several weeks if insufficient clinical improvement is observed. Administer doses above 20 mg/day once daily in the morning or twice daily (i.e., morning and noon).The maximum fluoxetine dose should not exceed 80 mg/day.
- In controlled trials used to support the efficacy of fluoxetine, patients were administered morning doses ranging from 20 to 80 mg/day. Studies comparing fluoxetine 20, 40, and 60 mg/day to placebo indicate that 20 mg/day is sufficient to obtain a satisfactory response in Major Depressive Disorder in most cases
Fluoxetin : Obsessive Compulsive Disorder
- Initial Treatment
- Adult — Initiate PROZAC 20 mg/day, orally in the morning. Consider a dose increase after several weeks if insufficient clinical improvement is observed. The full therapeutic effect may be delayed until 5 weeks of treatment or longer. Administer doses above 20 mg/day once daily in the morning or twice daily (i.e., morning and noon). A dose range of 20 to 60 mg/day is recommended; however, doses of up to 80 mg/day have been well tolerated in open studies of OCD. The maximum fluoxetine dose should not exceed 80 mg/day.
Fluoxetine : Bulimia Nervosa <->binge eating
• Initial Treatment
— Administer PROZAC 60 mg/day in the morning. For some patients it may be advisable to titrate up to this target dose over several days. Fluoxetine doses above 60 mg/day have not been systematically studied in patients with bulimia.In the controlled clinical trials of fluoxetine supporting its effectiveness in the treatment of Bulimia Nervosa, patients were administered fixed daily fluoxetine doses of 20 or 60 mg, or placebo.Only the 60 mg dose was statistically significantly superior to placebo in reducing the frequency of binge-eating and vomiting.
• Periodically reassess to determine the need for maintenance treatment.
Fluoxetine : Panic disorder
Panic Disorder
• Initial Treatment
— Initiate treatment with PROZAC 10 mg/day. After one week, increase the dose to 20 mg/day. Consider a dose increase after several weeks if no clinical improvement is observed
Fluoxetine doses above 60 mg/day have not been systematically evaluated in patients with Panic Disorder. In the controlled clinical trials of fluoxetine supporting its effectiveness in the treatment of Panic Disorder, patients were administered fluoxetine doses in the range of 10 to 60 mg/day. The most frequently administered dose in the 2 flexible-dose clinical trials was 20 mg/day. • Periodically reassess to determine the need for continued treatment.
Glimepiride
Recommended Dosing
- AMARYL should be administered with breakfast or the first main meal of the day.
- The recommended starting dose of AMARYL is 1 mg or 2 mg once daily. Patients at increased risk for hypoglycemia (e.g., the elderly or patients with renal impairment) should be started on 1 mg once daily
- After reaching a daily dose of 2 mg, further dose increases can be made in increments of 1 mg or 2 mg based upon the patient’s glycemic response. Uptitration should not occur more frequently than every 1-2 weeks. A conservative titration scheme is recommended for patients at increased risk for hypoglycemia.
- The maximum recommended dose is 8 mg once daily.
- Patients being transferred to AMARYL from longer half-life sulfonylureas (e.g., chlorpropamide) may have overlapping drug effect for 1-2 weeks and should be appropriately monitored for hypoglycemia.
Isotretinoin
초기용량
• 이소트레티노인으로서 1일 체중 kg당 0.5 mg을 반응을 관찰하며 투여
유지용량
- 이 약으로서 1일 체중 kg당 0.5～1.0 mg을 투여하며, 중증의 여드름 환자에게는 2.0 mg까지 증량할 수 있다. 저용량의 경우는 1일 1회, 고용량의 경우는 1일 2회 분할하여 식사와 함께 복용한다.
- 치료과정마다 체중 kg당 120 mg의 누적용량은 증상의 호전율을 높이고, 재발률을 낮춘다. 치료기간은 1일 복용량에 따라 달 라질 수 있으나 보통 16～24주가 소요되고, 치료중단 후에도 증상호전이 있을 수 있다. 따라서 증상이 재발될 경우 상기 치료 과정을 반복하되 최소한 8주간의 휴약기간이 경과된 후 치료를 재개해야 한다.
Accutane (isotretinoin) should be administered with a meal.
- The recommended dosage range for Accutane (isotretinoin) is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks.
- patients whose disease is very severe with scarring or is primarily manifested on the trunk may require dose adjustments up to 2.0 mg/kg/day, as tolerated. Failure to take Accutane (isotretinoin) with food will significantly decrease absorption. Before upward dose adjustments are made, the patients should be questioned about their compliance with food instructions.
- If the total nodule count has been reduced by more than 70% prior to completing 15 to 20 weeks of treatment, the drug may be discontinued. After a period of 2 months or more off therapy, and if warranted by persistent or recurring severe nodular acne, a second course of therapy may be initiated
- Long-term use of Accutane (isotretinoin) , even in low doses, has not been studied, and is not recommended. It is important that Accutane (isotretinoin) be given at the recommended doses for no longer than the recommended duration. The effect of long-term use of Accutane on bone loss is unknown
