1
Q
DPP4 MOA
A
Inhibit enzyme that activates incretin hormones
Increases insulin secretion in response to meals
2
Q
DPP4 expected change in A1c
A
Low
3
Q
How are DPP4 administered?
A
Orally
4
Q
DPP4 ADEs
A
Generally well tolerated
Nasopharyngitis, HA, HF
5
Q
DPP4 risk of hypoglycemia
A
Low
6
Q
DPP4 impact on weight
A
Neutral
7
Q
DPP4 CV impact
A
Neutral, may worsen HF outcomes
8
Q
DPP4 renal impact
A
Neutral
9
Q
DPP4 precautions/CIs
A
Renal dysfunction
10
Q
DPP4 drug interactions
A
CYP3A4/5 inhibitors
11
Q
DPP4 cost
A
High
