DRONEDARONE

Question 1

Indication

Answer 1

• Maintenance of sinus rhythm after cardioversion in clinically
  stable patients with paroxysmal or persistent AF, when alternative treatments are unsuitable
• initiated under specialist supervision

Question 3

CI

Answer 3

• HF
• Lung toxicity (interstitial lung disease, pneumonitis, pulmonary fibrosis)
• QT

Question 4

SE

Answer 4

• Heart tailure (if occurs discontinue)
• Bradycardia
• pulmonary toxicity
• Long QT syndrome
• Hepatoxicity

Question 5

How would you know if liver injury is occurring with dronedarone?
What must you do if it is occurring?

Answer 5

• AAT conc would exceed 3 x UL
• abdominal pain, anorexia, N&V, fever, dark urine, jaundice
• STOP

Question 6

How would you know if pulmonary toxicity is occurring with dronedarone? What must you do?

Answer 6

• symptoms such as dyspnoea
  (SOB) and dry cough
• Discontinue if it occurs

Question 7

What are the symptoms of HF that patients need to be warned about with dronedarone?

Answer 7

• Weight gain
• Oedema
• dysponea

Question 8

What are the monitoring requirements for dronedarone?

Answer 8

• Monitor for HF
• ECG every 6 months
• Serum creatinine 7 days before and after initiation
• Liver function