Droperidol

Question 1

Droperidol Introduction

Answer 1

• Droperidol is a neuroleptic, antipsychotic agent that acts on Alpha and Dopamine receptors, resulting in sedation
• Onset of effect usually 3-5 mins both IM and IV
• Use of a sedative agent should never be considered routine. Have a high threshold to offer or administer.

Question 2

Droperidol Indications

Answer 2

• Disturbed and Abnormal Behaviour (Generally RASS 1 ~ 3) if considered appropriate where risk to safety is evident and de-escalation has not been effective.
• Dementia or frail patients where Olanzapine cannot be administered or is ineffective

Question 3

Droperidol Contraindications

Answer 3

• Known allergy
• Known Parkinson’s Disease
• Where Ketamine has been administered to sedate this episode
• Age <6 years of age
• Post-ictal Disturbed & Abnormal Behaviour

Question 4

Droperidol Precautions / Notes

Answer 4

• Address organic causes for behavioural presentations at all times- eg. CVA, TBI, Hypoxia, Hypoglycaemia, etc
• Post-ROSC agitation - consult ASMA / SOC CSP
• Dementia patients – apply caution. Use lower doses
• ‘Agitated or Excited Delirium’, ‘Acute Behavioural Disturbance’ and ‘Drug Induced Psychosis’ are some alternative terms that may be used by other agencies

Question 5

Droperidol Special Considerations (Side Effects)

Answer 5

• Extrapyramidal effects / Dyskinesia
• Increased falls risk
• Hypotension
• Apply monitoring as soon as practicable