Step 1 of EC Coupling
Action potential generated and
propagated along sarcolemma
to T-tubules
Step 2
Action potential triggers Ca2+
release from sarcoplasmic reticulum
Step 3
Ca++ bind to troponin; blocking
action of tropomyosin released
Step 4
contraction via crossbridge
formation; ATP hyrdolysis
Step 5
Removal of Ca+2 by active
transport back into SR
Step 6
tropomyosin blockage restored;
contraction ends; Ion pumps will return calcium to the sarcoplasmic
reticulum, troponin and tropomyosin slide back in place,
and contraction stops