Where is the heart located?
In the mediastinum, above the diaphragm, behind the sternum, and in front of the spine.
What is the base of the heart?
The top of the heart.
What is the apex of the heart?
The bottom of the heart.
Approximate size and weight of the adult heart?
About 5 inches long, 3.5 inches wide, 2.5 inches thick, and 11 ounces. Roughly the size of the owner’s clenched fist.
What is the function of arteries?
Carry oxygenated and nutrient-rich blood away from the heart. Exception: Pulmonary artery carries deoxygenated blood from RV to lungs.
What is the function of veins?
Carry deoxygenated blood from the body to the heart. Exception: Pulmonary vein carries oxygenated blood from lungs to LA.
Function of capillaries?
Deliver oxygen and nutrients at the cellular level and carry deoxygenated blood back to veins.
What is the endocardium?
Inner layer of the heart; made of epithelial and connective tissue; lines cavities, covers valves, continuous with vessels; contains Purkinje fibers.
What is the myocardium?
Middle muscular layer of cardiac muscle fibers; contracts to pump blood from ventricles, relaxes to let atria fill.
What is the pericardium?
Fluid-filled double sac surrounding heart; protects from trauma/infection, prevents over-expansion, supports limited motion.
What is the epicardium?
Outer protective layer; contains coronary blood vessels and nerves. Also called visceral pericardium.
What are atrioventricular (AV) valves?
Valves separating atria from ventricles: tricuspid (RA → RV) and mitral/bicuspid (LA → LV).
What are semilunar (SL) valves?
Valves between ventricles and great arteries: aortic (LV → aorta) and pulmonic (RV → pulmonary artery).
What are chordae tendineae?
Tendon-like fibers connecting AV valves to papillary muscles, preventing prolapse during systole.
What are papillary muscles?
Ventricular muscles that contract with ventricles to hold valves shut through chordae tendineae.
Coronary artery circulation: what does the RCA supply?
RV, RA, inferior & posterior LV (~85%), SA node (~60%), AV node (~85%).
Coronary artery circulation: what does the LCA supply?
Splits into LAD and circumflex (CX). LAD: anterior LV, most of septum, part of lateral LV. CX: LA, lateral LV, inferior & posterior LV (~15%), SA node (~40%), AV node (~15%).
Why is the LAD called the ‘widow-maker’?
Blockage often causes sudden death due to loss of blood supply to large LV area.
What is pulmonary circulation?
Blood flow from heart → lungs → back to heart.
What is systemic circulation?
Blood flow from heart → body → back to heart.
Flow of blood through the heart (step order)?
Sympathetic vs parasympathetic effect on heart?
SNS: ↑HR, AV conduction, contractility (epi/norepi). PNS: ↓HR, ↓AV conduction (acetylcholine).
What is cardiac conduction?
System that controls the heart’s electrical activity to coordinate contractions and maintain blood flow.
What is the cardiac action potential?
Result of separated electrical charges (ions) creating potential energy, causing electrical activity in heart cells.