Time taken for 50% of administered drug to be eliminated
Half Life
When rate of elimination is directly proportional to drug concentration it is described as
First order
This phase of metabolism involves conjugation reactions
Phase 2
The main site of drug metabolism is
The Liver
Where in the cell are the enzymes involved in phase 1 metabolism found?
Smooth endoplasmic reticulum
Term used when rate of elimination is independent of drug concentration
Zero order
The enzymes responsible for of phase 2 metabolism are found mainly in the cell
Cytosol
The enzymes involved in Phase 1 metabolism
Cytochrome P450
Which phase of metabolism entails mainly oxidation reactions?
Phase 1