What is sepsis?
Life-threatening organ dysfunction caused by a dysregulated response to infection
What are the criteria to diagnose sepsis?
2 or more of the following: (temp/WCC must be one)
What is neonatal sepsis?
Sepsis within the first 28d of life.
EOS = <72hrs
LOS = 7-28d
What are the most common causes of neonatal sepsis?
Overall = GBS and E.coli
EOS = GBS
LOS = CoNS e.g. staph epidermidis
Also = staph aureus, strep pneumoniae
What are the RFs for sepsis?
What are the S/S of sepsis?
Respiratory = grunting, nasal flaring, use of accessory respiratory muscles, tachypnoea, apnoea, cyanosis
CNS = Infant: bulging fontanelle, irritability / Child: headache, photophobia, neck stiffness, seizures, decreased GCS
CVS = tachycardia, hypotension
GI = jaundice, V/D, abdominal pain, poor feeding, abnormal distention
General = lethargy, fever, hypothermia, purpuric rash
What are the investigations for sepsis?
PAEDIATRIC SEPSIS 6:
+ Urine MC&S
+/- LP
+/- CXR / abdo USS
What is the management of sepsis?
EMERGENCY, ABCDE approach
What are the causes of meningitis?
Neonates = GBS, E.coli, listeria monocytogenes
1m-6yrs = strep pneumoniae, n. meningitidis, h influenzae type B
> 6yrs = n. meningitidis, strep pneumoniae
Viral = enteroviruses, CMV, arbovirus
TB = most common 6m-6yrs
What are the RFs for meningitis?
Immunodeficiency
Environmental
What are the symptoms of meningitis?
Neonates = decreased activity, irritability, lethargy, seizures, fever or hypothermia, poor feeding
Children = headache, photophobia, neck stiffness, fever, non-blanching rash, lethargy, drowsiness, leg pain, N/V, alteration in consciousness, seizures
What are the signs O/E of menigitis?
What are the investigations for meningitis?
Blood cultures x2
Bloods (FBC, CRP, U&E, coagulation profile)
VBG (glucose, lactate)
Urine (dip, MC&S, culture)
LP = high polymorphs, high protein, low glucose
What are the contraindications for LP?
Signs of raised ICP (coma, high BP, low HR), thrombocytopenia, meningococcal septicaemia, cardiorespiratory instability, focal neurological signs, coagulopathy, local infection at LP site, causes undue delay in starting abx
What is the management of meningitis?
EMERGENCY, ABCDE approach
What is the follow-up for meningitis?
RV 4-6wks after discharge and discuss potential long-term complications
Describe viral meningitis
What are the causes of encephalitis?
What are the symptoms of encephalitis?
Same as meningitis
+++ Fever, altered consciousness, seizures
May not be able to differentiate clinically so begin tx for both (differentiate potentially by behavioural change)
What are the signs O/E of encephalitis?
Reduced GCS
Kernig sign
Cranial nerve and motor abnormalities
Ataxia (varicella-associated encephalitis)
What are the investigations for encephalitis?
Same as meningitis
+ MRI = hyperintense lesions, oedema, BBB breakdown
+ PCR = for viruses e.g. HSV
What is the management of encephalitis?
Medical emergency, ABCDE approach
CMV > add ganciclovir and Foscarnet
VZV > acyclovir/ganciclovir
What is anaphylaxis?
Type 1 hypersensitivity reaction (antigen cross-linking with IgE membrane bound antibody of mast cell or basophil)
What are the risk factors for anaphylaxis?
Parental atopy
Atopic eczema
Asthma
Allergic rhinitis