1
Q
how does metformin work
A
Metformin reduces hepatic glucose production (gluconeogenesis),
increases glucose uptake
increases insulin sensitivity
2
Q
when should metformin be decreased
A
as renal function falls
3
Q
sulfonyureas basic MOA
A
Act on the β-cell to induce insulin secretion
4
Q
adverse effects of sulfonyureas
A
weight gain
hypoglycaemia
5
Q
contraindication to pioglitazone
A
fluid retention can precipite heart failure
6
Q
side effects of pioglitazone
A
weight gain
fracture risk
mild anaemia
7
Q
where do sulfonyureas work
A
bind to SUR1 receptor
K+ ATP channel (closes) => Calcium channel opens which causes insulin release
2nd year
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