Basophilic cells in the anterior pituitary
B flat major (basophilic- fsh,lh, acth, tsh, msh)
Also called the oral ectoderm
Rathke’a pouch
Acidophilic cells
GH and prolactin
Produced in posterior pit
Vasopressin, oxytocin
Defect in FGF receptor 3
Achondroplasia
Excessive GH withour skeletal deformities
Gigantism
GTP is stimulated by
Guanine nucleotide exchange factors
GTP is inhibited by
GTPase accelerating proteins, RGS proteins
Defect in FGF receptor 3
Achondroplasia
Tx for central DM
DDAVP(adh analg)
Tx for peripheral diabetes insipidus
Thiazide diureics
SIADH
Demeclocyclne