what makes steroid hormones unique?
-hydrophobic (can go through cell membranes
-has membrane receptors and/or nuclear receptors
steroid hormones other
-synthesized on demand from precursors
-bound to carrier proteins
-turns genes on and off
-target is induction of new protein synthesis
peptide hormone examples
insulin, parathyroid hormone
-receptor in cell membrane
steroid hormone examples
estrogen, androgens, cortisol
-receptors in cytoplasm or nucleus, some have membrane
amine hormone examples
-epinephrine, norepinephrine, dopamine (cell membrane)
-thyroxine (T4) (nucleus)
peptide hormones are made ______ and act using_____
made in advance like every other protein; membrane receptors
peptide hormones other
-exocytosis from parent cell
-dissolved in plasma
-target is synthesis of proteins or modification
what are the three aspects of hormone response
1.how much hormone do I have?
2.how many receptors do I have to receive it?
3.what kind of receptors are they and where are they?
HPA axis
affects stress
-PVN of hypothalamus
-ADH and CRH are released to anterior pituitary
—stimulate ACTH
-ACTH stimulate cortisol, glucocorticoids, mineral corticoids, and DHEA
—DHEA is synthesized into sex hormone
HPG axis
affects reproduction
-hypothalamus produces GnRH
-to anterior pituitary stimulate release of LH and FSH
—LH and FSH trigger testosterone, estrogen, and progesterone