hormones
what happens when hormones are secreted into body fluids?
receptors
homeostatic control of hormone levels
- hormone levels too high, receptor down-regulation
what are the 6 types of intercellular communication?
Elephants Play And Sleep Nicely on Sundays
endocrine signaling
endocrine cells secrete hormones into extracellular fluid
-diffuse into bloodstream -> travel around body -> attach to receptors on target cells
short distance signaling
paracrine signaling
target cells NEAR secreting cells
autocrine signaling
target cells ARE secreting cells
synaptic signaling
neuroendocrine signaling
-neurosecretory cells - specialized neurons that secrete neurohormones, which diffuse into bloodstream
signaling by pheromones
phermones are chemicals that are released into the external environments
-target other individuals of same species to: define territory, warn of predators, attract mates
what are the two classes of local regulators?
2. gases
modified fatty acids
- ex: Prostaglandins - regulate many processes
gases
-ex: Nitric Oxide (NO)
-Blood O2 rises -> blood vessel lining releases NO
[diffuses to surrounding muscle]
[activates enzymes, relaxes cells]
[vasodilation]
how does solubility affect the response pathway?
water soluble hormones
-involves signal transduction (series of changes in cellular proteins that convert extracellular chemical signals into specific intracellular responses)
pathway of water soluble hormones
hydrophilic (cannot pass through membrane)
pathway for lipid soluble hormones
hydrophobic (cannot dissolve in blood, can cross CM)
how may target cells differ?
receptor and response molecule
epinephrine
endocrine
exocrine