endocrine therapy

Question 1

what % of breast cancers are hormone-sensitive

Answer 1

70%

Question 2

2 types of endocrine therapy

Answer 2

1. oestrogen deprivation
2. anti-oestrogens

Question 3

side effects of aromatase inhibitors (AIs)

Answer 3

can lead to osteoporosis

Question 4

examples of AIs

Answer 4

letrozole, anasrtozole

Question 5

What do SERMs do

Answer 5

modulate the binding of receptors so that signalling can’t happen

Question 6

example of SERM

Answer 6

tamoxifen

Question 7

examples of surgery as endocrine therapy

Answer 7

oophorectomy, adrenalectomy

Question 8

example of radiotherapy as endocrine therapy

Answer 8

radiotherapy to ovaries

Question 9

Fulvestrant

Answer 9

• oestrogen receptor (ER) antagonist
• downregulates ER

Question 10

premenopausal treatment strategies

Answer 10

ovarian ablation (surgery, RT, chemo) then tamoxifen

Question 11

postmenopausal treatment strategies

Answer 11

tamoxifen, selective AI, fulvestrant

Question 12

Adjuvant endocrine therapy

Answer 12

• the more positive the receptors are the more likely the therapy is going to help

Question 13

what is the oncotype score

Answer 13

specimen of cancer is sent to US and genes are proliferated, comes up w a score to signal if treatments are worth it