1
Q
Rank # & death
A
most common in women/ second leading cause of death
2
Q
incidence
A
~184K invasive & 67.7K in situ
3
Q
Trends
A
- ) Decreased incidence (no more postmenopausal hormonal therapy)
- ) Blacks: decrease incidence/increased mortality
4
Q
Risk Factors
A
Age: Overall, age at menarche, late age of first pregnancy, menopause,
family history,
dense breast on mammography,
exogenous estrogen
5
Q
% due to genetics
A
10%
p53 (LiFraumeni)
BRCA1
BRCA2
6
Q
BRCA1 Risk
A
40-85% lifetime risk breast cancer
25-65% life-time risk ovarian cancer
7
Q
BRCA 2 Risk
A
40-85% lifetime risk breast cancer
10-15% lifetime risk ovarian cancer
8
Q
BRCA Intervention
A
Prophylactic mastectomy: 100% risk reduction in breast cancer
Prophylactic BSO (Rubbeck et. al. 2009) Breast: 50% reduction in risk Ovarian/fallopian: 80% reduction
9
Q
Calcifications in DCIS
A
85-90%
RadOnc Breast
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