Epileptogenesis

Question 1

Traumatic brain injury is due to what mechanism?

Answer 1

Reduced GABAergic inhibition inter neurons

Question 2

Increased excitability is related to to what changes?

Answer 2

GABAergic inhibition and excitation

Question 3

GABAergic inhibition can be due to what?

Answer 3

Loss of inter neurons, alterations of chloride gradients in excitatory cells

Question 4

What can excitation increases be due to?

Answer 4

Axonal sprouting that causes aberrant recurrent excitation, loss of afferent inputs