Errors In Cell Cyle Control

Question 1

What do mitotic spindle fibres ensure?

Answer 1

Accuracy of chromosomes segregation

Question 2

What do centrosomes do?

Answer 2

Organise microtubules

Always 2

Question 3

What is aneuploidy?

Answer 3

Wrong number of chromosomes

Question 4

What does mitosis errors promote?

Answer 4

Numerical chromomes instability and tumour heterogenity which leads to plasticity of cancer

Question 5

What happens is there are amplified centrosomes?

Answer 5

Leads to multipolar spindles which promote numerical chromosomal instability
Cancer cells usually possess amplified centrosomes

Question 6

What can cancer cells do to centrosomes so they do not die?

Answer 6

Cluster them

Drugs can be produced to stop this