ESAP 2011

Question 1

What’s the most common cause of rapid virilization in women of reproductive age?

Answer 1

Sertoli-Leydig cell tumor (arrhenoblastoma)

Question 2

What is the strongest type 2 diabetes susceptibility gene to date?

Answer 2

TCF7L2

Question 3

What is the difference between arrhenoblastoma and ovarian hyperthecosis in terms of virilization?

Answer 3

Arrhenoblastoma causes rapid virilization.

Ovarian hyperthecosis causes severe but slower (years) virilization.