0
Q
Mech of action
A
Depresses reticular activating system of the brain and potentiates GABA > causes sedation
1
Q
Class
A
Sedative/ Hypnotic
2
Q
Pharmakokinetics
A
Onset- 10-20 seconds
Peak- <1minute
Duration- 3-5 minutes
HL- 30-70 minutes
3
Q
Indications
A
Induction agent for RSI
4
Q
Contraindications
A
Hypersensitivity
5
Q
Side effects
A
Myoclonic skeletal muscle movement, apnea, hyperventilation, hypoventilation, laryngospasm, HTN, hypotension, tachycardia, bradycardia, NV
6
Q
Dose
A
Adult- 0.3mg/kg IV, IO over 15-30 seconds
Pedi- same
7
Q
Precautions
A
Consider alternate sedative in patients with severe asthma
8
Q
Drug - Drug
A
May prolong respiratory depression and apnea with Verapamil
RSI
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