causes of ckd (rank)
**in ckd what are the 5 functions affected and hence clinical presentation
criteria for ckd
egfr < 60 ml/min/1.73m2 for more than 3 months OR at least one: albuminuria, hematuria, electrolyte acid-base imbalances and imaging showing structural abnormalities
eskd criteria
irreversible kidney dysfunction with eGFR < 15 mL/min/1.73 m2
OR
manifestations of uremia requiring chronic renal replacement therapy
what are ultrasound findings suggestive of ckd
**acute management for ckd/indications for emergency dialysis
AEIOU
- refractory metabolic acidosis
- refractory hyperk
- intoxication
- overload
- uremic
insert central venous catether for immediate access if patient does not have a permenant mature avf
**chronic ckd mgt
how to manage acute refractory hyperk
how much sodium and protein per day in ckd patients?
na <2g/day
protein < 0.8g/kg/day
chronic mgt of hyperk
how to treat the different uremic emergencies
uremic encephalopathy or pericarditis -> urgent dialysis via CVC
how to manage fluid overload in ckd pt
what is esrf in terms of ckd
ckd stage 5
management of esrf
renal replacement therapy
1. hemodialysis
2. peritoneal dialysis
3. renal transplant
types of dialysis for renal
how long does it take for avf to mature
6 weeks
what are signs of maturity in avf?
palpable thrill and audible bruit, easily cannulated and sustain repeated needle punctures w/o infiltration or hematoma
PD vs HD
PD
- home based therapy
- painless
- risk of peritonitis
- treatment must be done 4 times per day
- no surgery
HD
- avf very common - either brachiocephalic or radiocephalic
- av graft is used when patient’s arteries or veins are unsuitable to be used (collapsed, small)
- need surgery
- ijv tunnelled catether allows for non-surgical HD
clinical symptoms of nephrotic syndrome
PEAS
- proteinuria (severe, >3.5g/day)
- edema
- albumin (low)
- serum lipids and cholesterol low
causes of nephrotic syndrome
**diabetic nephropathy
young: mcd
old:
focal segmental glomerulosclerosis
membranous GN
membranoproliferative GN
secondary:
lupus nephritis
amyloid nephropathy in multiple myeloma & RA
describe the immunofluorescence i will see for diabetic nephropathy
effacement of podocytes
complications of nephrotic syndrome
ckd
renal vein thrombosis
thromboembolism (dvt)
severe proteinuria:
- less immunoglobulins -> more prone to infxn
- anemia
- hypothyroidism
- vitamin deficiency
- protein malnutrition
quantitative assessment of nephrotic syndrome
what is the lupus nephritis “full house” pattern?
IgG, IgM, IgA, C3, C1q