Iron deficiency anemia
Decreased iron stores the oxygen carrying ability of the RBC due to inability to form adequate hemoglobin.
Iron deficiency anemia symptoms
Brittle nails, smooth, red tongue, angular cheilitis, SOB, fatigue, tachycardia, pallor, dizziness/syncope.
Iron deficiency anemia diagnosis
CBC, MCV, MCH, iron studies: TIBC, ferritin.
Iron deficiency anemia treatment
Treat underlying cause, nutrition education, iron supplements, epoetin alfa (monitor Hgb, Hct, and iron studies to ensure therapeutic effects, monitor BP and K+ as common side effects can be hypertension and hyperkalemia).
Pernicious Anemia
Decrease in vitamin B12 that is required to convert folic acid to its active form. Could be due to lack of intrinsic factor in the gut.
Pernicious Anemia symptoms
Pallor, sore, cracked, red tongue, anorexia, nausea/vomiting, weakness, paresthesias, ataxia, cognitive issues.
Pernicious Anemia diagnosis
CBC, MCV, Schilling test, serum B12 levels.
Pernicious Anemia treatment
B12 supplements.
Folic acid anemia
Decrease in folic acid alters the process of DNA synthesis and differentiation of RBC precursors.
Folic acid anemia symptoms
Fatigue, pallor, weakness, SOB, sore tongue, neural tube defects in pregnant women.
Folic acid anemia diagnosis
CBC, MCV.
Folic acid anemia treatment
Folic-acid supplements, diet.
Aplastic anemia
A lack of cells produced by the bone marrow.
Aplastic anemia symptoms
Fatigue, pallor, weakness, SOB, frequent infections, easy bleeding and bruising.
Aplastic anemia diagnosis
CBC, Bone marrow biopsy.
Aplastic anemia treatment
Immunosuppressants, colony stimulating factors, blood products transfusions.
Sickle cell anemia
Normal hemoglobin is replaced by abnormal hemoglobin which cause RBCs to sickle and stick together more easily.
Sickle cell anemia symptoms
Fatigue, SOB, fever, swelling, tenderness, hypertension, jaundice, pain, end-organ damage.
Sickle cell anemia diagnosis
CBC, hemoglobin electrophoresis, sickle cell turbidity test.
Sickle cell anemia treatment
IV fluids, supplemental O2, hydroxyurea, blood transfusions, analgesics (only cured by bone marrow stem cell transplant).
Erythropoiesis
Process of red blood cell formation occurring in the red bone marrow, stimulated by erythropoietin from kidneys, triggered by hypoxia.
Nutrients needed for erythropoiesis
Iron, B12, folate, protein.
Complications from anemia
Cardiovascular strain, neurologic and cognitive effects, respiratory changes, hypoxia organs, impaired healing and immunity.
Role of the spleen in anemia
Acts as a quality-control organ for RBCs—filtering, destroying, and storing them.