Hormones
Chemicals secreted by cells in one part of the body that travel through the bloodstream to act on target organs or tissues elsewhere in the body.
Endocrine glands
Glands that release hormones directly into the bloodstream (no ducts).
Major endocrine structures
Hypothalamus, pineal gland, pituitary gland, thyroid, adrenal gland, pancreas, gut, and gonads.
Exocrine glands
Glands that use ducts to secrete substances outside the body, such as sweat or tears.
Endocrine vs Exocrine
Endocrine releases hormones internally into blood
Endocrine communication
Hormones released into the bloodstream affect distant target tissues.
Neurocrine (synaptic) communication
Neurons release neurotransmitters across synapses to target cells.
Autocrine communication
A cell releases a chemical that acts on itself through autoreceptors.
Paracrine communication
A cell releases chemicals that diffuse to nearby target cells.
Pheromones
Chemical signals released into the environment to communicate with members of the same species.
Allomones
Chemicals released by one species that affect the behavior of another species.
General principles of hormone action
Hormones act gradually, influence behavior probability/intensity, and have reciprocal relationships with behavior.
Additional hormone principles
Hormones often act in bursts (pulsatile release), follow circadian rhythms, can interact with other hormones, and only affect cells with matching receptors.
Peptide (protein) hormones
Short chains of amino acids that act quickly and bind to cell surface receptors, activating second messenger systems.
Amine hormones
Modified single amino acids (monoamines) that also act quickly through surface receptors.
Steroid hormones
Derived from cholesterol, they pass through cell membranes and bind to intracellular receptors to alter gene expression (slower but longer-lasting effects).
Central Dogma
DNA → mRNA → Protein
Steroid receptor effect
Steroid hormones bind receptors inside cells, directly influencing transcription and protein synthesis.
Steroid genomic effect
Long-term change in gene expression due to steroid-receptor complexes binding DNA.
Negative feedback mechanism
A system where a hormone’s effects inhibit further secretion, maintaining balance.
Autocrine feedback
Hormone acts on the same endocrine cell that secreted it to inhibit further release.
Target cell feedback
The biological effects of a hormone reduce its own further release by signaling the endocrine gland.
Brain and pituitary feedback regulation
The hypothalamus and pituitary detect hormone levels and adjust release to maintain homeostasis.
Releasing hormone
Produced by the hypothalamus to control pituitary hormone release.