1
Q
What are GPCRs?
A
7 transmembrane receptor proteins that signal via activation of heterotrimeric GTPases– GPCRs can interact with different GTPases
2
Q
how do GPCR’s work?
A
ligand binding causes a conformational change, activating intracellular G protein, which binds GTP and hydrolyzes it to GDP and Pi
3
Q
three major families of heterotrimeric G proteins
A
G alpha s
G alpha i
G alpha q
4
Q
How do GPCRs help with signal amplification?
A
- one ion channel lets many calcium ions pass
- one cyclase can make many molecules of cAMP or cGMP
- one kinase phosphorylates many proteins
- one transcription factor makes many mRNAs
5
Q
benefit of signal amplification
A
allows for high sensitivity in translating messages received by the cell
6
Q
A
NSC 4352 Cellular Neuroscience
flashcards
Decks in class (3)
# Cards
