Exam 3 Prototypes

Question 1

MAO Inhibitors (4)

Answer 1

TIPS

Tranylcypromine (Parnate)
Isocarboxazid (Marplan)
Phenelzine (Nardil)
Selegiline (EMSAM) MAO-B at low dose and MAO-A at high doses

Question 2

TCA

Answer 2

imipramine (Tofranil)

Question 3

SNRI

Answer 3

venlafaxine (Effexor XR)

Question 4

SSRI

Answer 4

fluoxetine (Prozac)

Question 5

Gout Drugs (4)

Answer 5

NSAIDS- no specific prototype
Glucocorticoids- prednisone
Colchicine
Allopurinol

Question 6

Osteoporosis Drugs (7)

Answer 6

1. Calcium and Vit D supplementation
2. Calcitonin-salmon
3. Alendronate (bisphosphonate)
4. Conjugated equine estrogen
5. Raloxifene (SERMS)
6. Teriparatide (parathyroid hormone)
7. Denosumab (monoclonal antibody)

Question 7

RA Drugs (4)

Answer 7

1. NSAIDS- no specific prototype
2. Glucocorticoids- prednisone
3. DMARDs nonbiologic- methotrexate
4. DMARDs biologic- etanercept

Question 8

Sedative/Hypnotic Drugs (2 Classes, 6 drugs)

Answer 8

Benzodiazepines: triazolam (Halcion), lorazepam (Ativan), diazepam (Valium), alprazolam (Xanax), midazolam (Versed)

Benzodiazepine-like drugs: zolpidem (Ambien)

Question 9

Anxiolytic Drugs (3 Classes)

Answer 9

1. Serotonin reuptake Inhibitors (SSRI and SNRI): no prototype now. Will discuss with depression
2. Benzodiazepines: diazepam (Valium)
3. Non-Benzodiazepine/Non-Barbiturate: buspirone (Buspar) and hydroxyzine

Question 10

Anti Epileptic Drugs (6)

Answer 10

Traditional

1. phenytoin (Dilantin)
2. fosphenytoin
3. carbamazepine (Tegretol)
4. valproic acid (Depakote)

Newer Agents

1. gabapentin (Neurontin)
2. pregabalin (Lyrica)

Question 11

Parkinson’s Drugs (6)

Answer 11

1. Levodopa/carbidopa (Sinemet)
2. Dopamine Agonist: pramipexole (Mirapex)
3. COMT Inhibitor: entacapone (Comtan)
4. MAO-B Inhibitor: selegiline (Eldepryl)
5. Antiviral: amantadine
6. Anticholinergic

Question 12

Alzheimer’s Drugs (2)

Answer 12

1. Cholinesterase inhibitor: donepezil (Aricept)

2. NMNA antagonist: memantine (Namenda)