1
Q
- Which of the following conditions associates hypercalcemia with hypophosphatemia:
a. Anorexia nervosa
b. Primary hyperparathyroidism
c. Turner syndrome
d. Zollinger-Ellison syndrome
e. Hypothyroidism
A
2
Q
- A scintiscintigraphy done in a patient with a toxic thyroid adenoma reveals:
a. Multiple functioning nodules in the gland
b. A hot nodule, with diminished or absent uptake in the contralateral lobe
c. Irregular, patchy distribution of radioactive iodine
d. An elevated diffuse uptake of iodine
e. No image can be detected
A
b. A hot nodule, with diminished or absent uptake in the contralateral lobe
3
Q
- The following may occur in the patient with hypothyroidism:
a. Pretibial myxedema
b. Bradycardia
c. Weight gain
d. Wet and warm skin
e. Hyperprolactinemia
A
b. Bradycardia
c. Weight gain
e. Hyperprolactinemia
4
Q
- Which of the following forms of thyrotoxicosis associates suppressed TSH with low radioiodine uptake?
a. Tireotropinoma
b. Toxic adenoma
c. Struma ovarii
d. Graves disease
e. Functional metastatic follicular thyroid carcinoma
A
c. Struma ovarii
5
Q
- Mention the forms of thyrotoxicosis with increased radioiodine uptake:
a. Graves disease
b. Subacute thyroiditis
c. Autonomous nodule
d. Toxic multinodular goiter
e. Struma ovarii
A
a. Graves disease
c. Autonomous nodule
d. Toxic multinodular goiter
6
Q
- Risk factors for osteoporotic fractures includes all the following EXCEPT:
a. Familial history of hip fracture
b. Primary hyperparathyroidism
c. Cushing disease
d. Acromegaly
e. Advanced age
A
a. Familial history of hip fracture
d. Acromegaly
7
Q
- Secondary hyperaldosteronism may occur in:
a. Renal artery stenosis
b. Cirrhosis
c. Cardiac failure
d. Nephrotic syndrome
e. Hypothyroidism
A
a
d
8
Q
- A 9 years old girl with Tanner stage 1 has delayed pubertal development:
a. Has delayed puberty
b. Has precocious puberty but with treatment the final height will be normal
c. There is no available treatment to improve the final height
d. GH treatment is the best treatment option for her
A
b. Has precocious puberty but with treatment the final height will be normal
9
Q
- Which of the following signs and symptoms are suggestive of male testosterone deficiency:
a. Gynecomastia
b. Increase in strength and muscle tonus
c. Body hair reduction
d. Decreased libido
e. Memory disorders
A
a. Gynecomastia
c. Body hair reduction
d. Decreased libido
e. Memory disorders
10
Q
- The following statements are TRUE regarding medullary thyroid carcinoma:
a. Is the most common type of thyroid cancer
b. It is less aggressive than papillary carcinoma
c. In about 80% of cases is associated with familial syndromes
d. Thyroglobulin is an useful post-operative marker for cancer recurrence
e. None of the above
A
e. None of the above
11
Q
- The following features of thyroid nodules are suggestive for malignancy:
a. Slow growth
b. The presence of the peripheral halo at ultrasound assessment
c. Predominantly peripheral vascularization of the nodule at ultrasound assessment
d. Family history of multinodular goiter
e. None of the above
A
e. None of the above
12
Q
- The following investigations are mandatory in the evaluation of a thyroid nodule over 1 cm in size:
a. Anterior cervical computed tomography
b. Fine needle aspiration
c. Serum thyroglobulin level
d. Evaluation of thyroid function
e. Thyroid ultrasound
A
b. Fine needle aspiration
d. Evaluation of thyroid function
e. Thyroid ultrasound
13
Q
- Which of the following drugs are used to treat osteoporosis?
a. Oral glucocorticoids
b. Bisphosphonates
c. Somatostatin analogues
d. Dopaminergic agonists
e. Lithium
A
b. Bisphosphonates
14
Q
- The following can cause hypercalcemia:
a. Primary hyperparathyroidism
b. Thyrotoxicosis
c. Osteolytic metastasis
d. Secondary hyperparathyroidism
e. Vitamin D intoxication
A
a. Primary hyperparathyroidism
b. Thyrotoxicosis
c. Osteolytic metastasis
e. Vitamin D intoxication
15
Q
- Cushing syndrome includes:
a. Cushing hormone secretion
b. Adrenal adenoma
c. Cushing disease
d. Iatrogenic Cushing syndrome (exogenous intake)
A
16
Q
- The following are true regarding pheochromocytoma:
a. They could cause severe hypertension
b. They are usually large tumors
c. They are usually small tumors
d. 50% are bilateral
e. Mitotan could be used in treatment
A
a. They could cause severe hypertension
b. They are usually large tumors
17
Q
- Which of the following conditions are causes of secondary endocrine hypertension:
a. Primary hyperaldosteronism
b. Conn disease
c. Acromegaly
d. Congenital adrenal hyperplasia due to 21-hydroxylase
e. Pituitary apoplexy
A
a. Primary hyperaldosteronism
b. Conn disease
c. Acromegaly
18
Q
- The following are typical clinical signs of glucocorticoid excess:
a. Thin, white abdominal striae
b. Frequent bruising at minimal trauma
c. Proximal myopathy
d. Moon-like face
e. Hirsutism
A
b. Frequent bruising at minimal trauma
c. Proximal myopathy
d. Moon-like face
e. Hirsutism
19
Q
- In which of the following situation we usually find hypoglycemia?
a. Acromegaly
b. Cushing disease
c. Addison disease
d. Hyperprolactinemia
e. Polycystic ovary syndrome
A
c. Addison disease
20
Q
- In a boy the short stature could be due to:
a. Turner syndrome
b. Prader-Willi syndrome
c. Hyperthyroidism
d. GH def
e. corticosteroids treatment for asthma
A
b. Prader-Willi syndrome
d. GH def
e. corticosteroids treatment for asthma
21
Q
- In a child with -3.5 SDS for height, the GH value during the clonidine stimulation test is 2.4 ng/ml, and the GH value during the insulin stimulation is 7 ng/ml, with a normal pituitary MRI, the following statements are true:
a. The diagnosis is GH deficiency
b. The diagnosis is short idiopathic stature
c. The therapeutic indication for treatment with somatropin
d. Somatropin treatment is contraindicated because he has no GH deficiency
e. Somatropin treatment is contraindicated because he has no low stature
A
a. The diagnosis is GH deficiency
c. The therapeutic indication for treatment with somatropin
22
Q
- The following statements about infertility are:
a. Is defined as the inability of a couple to conceive within 1 year of sexual intercourse
b. PCOS is a rare cause of infertility
c. Male factors could be involved
d. GnRH administration is the best option in pituitary macroadenoma
e. In vitro fertilization is the first step of treatment for any cause of infertility
A
a. Is defined as the inability of a couple to conceive within 1 year of sexual intercourse
c. Male factors could be involved
23
Q
- The following could be due to an ovarian dysfunction:
a. Hirsutism
b. Polydipsia
c. Skin hyperpigmentation
d. Facial plethora
e. Anovulation
A
e. Anovulation
24
Q
- A 33 years woman has had amenorrhea for 6 months. Her pregnancy test is negative. The serum FSH is high and serum estradiol is low. These data suggest:
a. Panhypopituitarism
b. Uterine adherences
c. Polycystic ovary syndrome
d. Oral contraceptives intake
e. Primary ovarian lesion
A
e. Primary ovarian lesion
25
78. Specify the correct statements in a male with growth hormone deficiency:
a. May present with increased fat mass
b. May associate dyslipidemia
c. The oral glucose tolerance test is used for positive diagnosis
d. The dexamethasone suppression test is used for positive diagnosis
e. It may be substituted with human recombinant GH
a. May present with increased fat mass
b. May associate dyslipidemia
e. It may be substituted with human recombinant GH
26
79. What are the correct statements about a patient diagnosed with a prolactin secreting pituitary macroadenoma:
a. Neurosurgical treatment is carried out primarily
b. The patient may clinically present with infertility and reduced libido
c. One of the goals of the drug treatment is the disappearance of the tumor
d. Treatment consists of dopamine agonists
e. Treatment consists of somatostatin analogues
B. The patient may clinically present with infertility and reduced libido
C. One of the goals of treatment is the disappearance of the tumor
D. Treatment may be done with dopamine agonists
27
80. The following statements are TRUE regarding the pathogenesis of endocrine disorders:
a. Both excessive hormone production and its reduction are implicated in the onset of endocrine disorders
b. Alteration of hormonal biorhythm can lead to endocrine disorders
c. GH receptors defect can lead to Laron nanism
d. Feminizing testicle is caused by androgen hormone resistance
e. All the answers above
E. all the answers above
28
82. MEN 1:
a. It is a familial tumoral syndrome characterized by mutations in the menin gene
b. It is characterized by pituitary, thyroid and endocrine pancreatic tumors
c. It is characterized by pituitary, thyroid, and endocrine pancreatic tumors
d. It is characterized by pituitary tumors, hyperthyroidism and pheochromocytoma
e. It is characterized by adrenal tumors, neurofibromas and marfanoid habitus
A. it is a famillial tumoral syndrome characterized by mutations in the menin gene
B. It is characterized by pituitary, parathyroid and endocrine pancreatic tumors
29
83. A 52-year-old woman presents to your office accusing the increase in the size of the extremities, the decrease in peripheral vision, and the fact that she requires increasing amounts of insulin to control her diabetes diagnosed about four years ago. At the clinical examination, you notice macroglossia, BP = 170/90 mmHg, hepatomegaly. Which of the following statements are true about your patient?
a. Probable diagnosis is a pituitary macroadenoma secreting GH
b. She may associate carpal tunnel syndrome
c. The diagnosis is based on IGF1 and mean GH 24h measurement
d. The diagnosis is based on the dexamethasone inhibition test
e. First-line treatment is radiotherapy
A. Probable diagnosis is a pituitary macroadenoma secreting GH
B. She may associate carpal tunnel syndrome
C. The diagnosis is based on IGF1 and mean GH/ 24h measurement
30
84. A 28-year-old woman is admitted with polydipsia (approximately 5 l/day). What could be the reason of this symptom:
a. Diabetes mellitus
b. Hypocalcemia
c. Idiopathic central insipidus diabetes
d. Sarcoidosis with pituitary stalk infiltration
e. All of the above
A. Diabetes mellitus
C. Idiopathic central insipidus diabetes
D. Sarcoidosis with pituitary stalk infiltration
31
85. For the treatment of Graves ophthalmopathy, you may use:
a. Artificial tears
b. Nonsteroidal anti-inflammatory drugs
c. Increased salivary
d. Pulse therapy with methylprednisolone
e. Surgery of eyeball extrinsic muscles
f. Radioactive iodine
A. Artifical tears
C. Pulse therapy with methylprednisolone
D. Surgery of eyeball extrinsic muscles
32
86. The risk factors for Graves ophthalmopathy that can be prevented are the following:
a. Male gender
b. Thyroid dysfunction
c. Old age
d. Smoking
e. All of the above
b. Thyroid dysfunction
d. Smoking
33
87. Treatment of thyrotoxic crisis includes:
a. Antithyroid synthesis drugs
b. Betablockers
c. Radioactive iodine
d. Glucocorticoid
e. Levothyroxine
A. Antithyroid synthesis drugs
B. Beta blockers
D. Glucocorticoids
34
88. Before establishing the diagnosis of polycystic ovary syndrome the following conditions should be excluded:
a. Diabetes insipidus
b. Congenital adrenal hyperplasia
c. Hyperprolactinemia
d. Pheochromocytoma
e. Primary hyperparathyroidism
B. Congenital adrenal hyperplasia
C. Hyperprolactinemia
35
89. The following are causes of central diabetes insipidus:
a. Pituitary tumors that compress the pituitary stalk
b. Sarcoidosis
c. Chronic renal diseases
d. Hypercalcemia
e. Idiopathic
A. Pituitary tumors that compress the pituitary stalk
B. Sarcoidosis
E. idiopatic
36
90. The following are causes of secondary endocrine hypertension:
a. Conn disease
b. Hashimoto thyroiditis
c. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
d. Cushing disease
e. Diabetes insipidus
A. Conn disease
C. Congenital adrenal hyperplasia due to 17-hydroxylase deficiency
D. Cushing disease
Endocrinology exam
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