0
Q
T/F:
Meloxicam (MOBIC) is considered to be a propionic acid derivative
A
False
1
Q
T/F:
Caffeine potentiates analgesic action of analgesics
A
True
2
Q
T/F:
Aspirin should be avoided in children and adolescents up to 18 years of age
A
True
3
Q
T/F:
NSAIDS irreversibly inhibit platelet aggregation
A
True
4
Q
T/F:
Indomethacin (Indocin) is considered to be an acetic acid derivative
A
True
5
Q
T/F:
Ibuprofen (Advil) is considered to be a propionic acid derivative
A
True
6
Q
T/F:
Piroxicam (Feldene) is considered to be an Oxicam
A
True
7
Q
T/F:
Probenecid decreases the levels of NSAIDs and penicillin
A
False
8
Q
T/F:
Fiorinal is an aspirin containing product that given by prescription only
A
True
9
Q
T/F:
Hydromorphone is more potent than morphine and better absorbed orally
A
True
10
Q
T/F:
A patient who feels nauseated after taking codeine is allergic to it
A
False
11
Q
T/F:
The normal maximum dose of acetaminophen is 2 gm
A
False
12
Q
T/F:
Aspirin should be avoided in children and adolescents up to 18 years of age
A
True
13
Q
T/F:
Mixed opioid agonist-antagonist have more of an abuse potential then pure opioid agonist
A
False
14
Q
T/F:
The FDA pregnancy category for opioids is B
A
False
15
Q
T/F:
Aspirin and acetaminophen are equal in both potency and efficacy
A
True
16
Q
T/F:
Phenacetin was removed from the market in the early 1980s because it cause methemoglobinemia was more toxic then acetaminophen
A
True
17
Q
T/F:
It is okay to take aspirin with antihypertensives
A
False
18
Q
T/F: Dental pain (e.g., pain after an extraction) is not useful as a method of testing analgesic efficacy
A
False
19
Q
T/F:
True opioid allergy is very uncommon
A
True
20
Q
Attempts to relieve pain while reducing toxic effects and dependency
A
Mixed opioids agonist/antagonist
21
Q
Is the prototype opioid
A
Morphine
22
Q
(Dolobid) is a salicylate classified as an NSAIA; that can be administered before dental procedures to delay the onset of postsurgical pain
A
Diflunisal
23
Q
Is made of hydrocodone and acetaminophen
A
Loracet
24
Stimulates the oxidizing enzymes that metabolize acetaminophen to its toxic metabolite
Alcohol
25
Is the drug of choice for treatment of dental pain when NSAIA is indicated
Ibuprofen
26
Naproxen sodium is classified as
Propolonic acid
27
mg every 4 to 6 hours is the usual analgesic dose of ibuprofen
400-800
28
What is the MOA aspirin
Inhibition prostaglandin synthesis
29
Imparts the characteristic vinegar odor to a bottle of aspirin
Acetic acid
30
What receptors are responsive to morphine
Mu, delta
31
What receptors are responsive to Naloxone
Mu, delta, kapa
32
What receptors are responsive to Pentazocine
Kappa
33
Should avoid Tylenol
Alcoholics
34
Receptors are involved in producing analgesia
Mu, kappa
35
Codeine ______ pain threshold. It affects the cerebral_____ to depress the _____ to pain
Raises
Cortex
Reaction
36
(diphenoxylate) is a opioid used to treat diarrhea
Lomotil
37
What are the four pharmacologic effects of opioids
Analgesic
Cough suppression
G.I. effect
Sedation and euphoria
38
What are the four A's of aspirin
Anti-inflammatory
Analgesic
Antipyretic
Antiplatelet
40
What are the three main adverse reactions of opioids
Respiratory depression
Nausea and Emesis
Constipation
40
Use for and adverse effect of while used with aspirin: probenecid (Benemid)
Prevent gout
| Increase Acute attack of gout
41
Use for and adverse effect of while used with asprin: warfarin (Coumadin)
Anticoagulant
| Bleeding or hemorrhage
42
Use for and adverse effect of while used with aspirin: tolbutamide (orinase)
Treat diabetes
| Hypoglycemic effect
43
Use for and adverse effect of while used with aspirin: methotrexate (MTX)
Treat cancer and arthritis
| Leads to bone marrow suppression
44
Use for and adverse effect of while used with aspirin: alcohol
Nontherapeutic
| Increase bleeding or hemorrhage
45
Use for and adverse effect of while used with aspirin: other anti-inflammatory drugs
Pain and arthritis
| Increased bleeding
46
A unique analgesic that has mu opioid agonist action and inhibits the reuptake of norepinephrine and serotonin
Tramadol
47
Contains 50mg of pentazocine and 0.5mg of naloxone
Pentazocine (Talwin)
48
The favorite drug of abuse of medical personnel
Meprederine
49
An orally effective agent reserved for severe pain
Dilaudid
50
A synthetic agent that is chemically similar to methadone the trade name is
Proproxopine
| Darvocet 100
51
Empirin # 4 is made of
Aspirin and 60mg codine
52
Tylenol #3 is made of
30mg codeine& Acetaminophen
53
Codeine #1 is ______mg and _____gr
7.5
| 1/8
55
Naloxone is a pure opiate antagonist that is active________.
| _________ is a parenteral opioid antagonist used to _______ opioid overdose.
Parenterally
Nalmefemene
Reverse
56
60 mg codeine has an analgesic strength about the same as ________ of aspirin or acetaminophen or______ of ibuprofen
650mg
| 200mg
57
Percocet=_____+______
oxycodone
| acetamenophen
58
Percodan=_______+______
oxycodone
| asprin
59
target organ for the antipyretic effects of Tylenol
hypothalmus
60
where is the cough center located?
medulla of brain
61
Vioxx or Celebrex are examples of
COXII inhibitors
62
an inherited disease occurring primarily in men, with an onset that usually involves one joint, often the big toe or knee
gout
63
____ and ____ are used to tx acute attacks of gout
NSAIDS
| colchine
64
____ and _____ are used to prevent gout
probenecid
| allopuronol
65
thromboxane A2 works w/ asprin and ____ aggregation
stimulants
66
most common adverse reactions to asprin
GI effects
vomiting
nausea
bleeding
67
before administerine butorphanol HCL (Stadol), the nurse asks the pt if he has used opiates. That's because administering a mixed opioid agonist-antagonist to a pt dependent on opioid agonist-antagonist to a pt dependent on opiod agonists may cause what reactions
withdrawl symptoms
68
the cause of death from overdose of any central nervous system depressant is usually
respiratory depression
69
a pt taking one tab of Tylenol #3 will be getting ____ mg of codine
30
70
pt taking warfarin (comadin) should not be given
asprin
71
in overdose, acetaminophen adverselhy affects what organ
liver
72
what should be given to a pt who has inflammation present at the site of pain
ibuprofen
73
the effects of asprin on the platelets lasts about how long
5 days
74
____ mechanism of action is primarily peripheral and a prostaglandin systhesis inhibitor
Asprin & NSAIDS
75
examples of NSAIDS are
ibuprophen, naproxen, advil, motrin
76
both acetaminophen and asprin have ____ effect
analgesic and antipyretic
77
asprin acts as an
salicylate
78
salicylates are not the drug of choice for patients
gastric ulceration, hemmorage, anticoagulant
79
ibuprofen (motrin) is useful for what
NSAID
80
the most serious side effect of narcotic analgesics is their ability to
respiratory destress
81
Darvon compound 65
combo of asa and cafine
82
percodan
asa
83
midol caplets
asa
84
carvocet N 100 combo of
acetaminophen and proxipropene
85
most effective antitussive medication
codine
86
analgesic raises pain thresholds (meaning, increasing pain tolerance or reducing pain) without impairing alertness or judgement
salycylate
87
action of ASA (asprin)
analgesic, antipyretic, antinflammatory, antiplatelet
88
drug of choice for tx of dental pain when a NSAID indicated
ibuprofen
89
acetaminophen (tylonol) has what actions
antipyretic analgesic
90
pure opoid antagoins; its in the dental emergency kit to treat an overdose of narcotic analgesic
codine
91
you have a pt who presents for a cleaning. while taking vitals you notice he seems to have an increased body temp. he begins to complain of ringing in the ears and is experiencing altered sensorium. what is pt suffering from?
salicylism
92
drug has anti-inflammatory, antipyretic, analgesic, and antiplatelet actions
aspirin
93
all of the following meds contain codeine except one. therefore, which of the following would a physician or dentist prescribe for a client in paint who is allergic to codiene
Darvocet
94
know what Darvocet is made of
propayphenon apslate 100 mg; 4 acetaminophen 650 mg
95
nonsteroidal anti-inflammatory drugs such as ibuprofen, indomethacin, and naproxen can reduce the pharmacologic effect of
ace inhibitors
96
aspirin can produce
GI side effects
97
strongest analgesic effect
ibuprofen 600mg
98
what is an adverse reaction to the opioids
respiratory depression
99
which 2 of the following could be given most safety to a pt who is allergic to codeine
ibuprofen, dexatroproxypheric
100
most efficacious?
oxycodone
101
drug of choice to tx pt who has taken overdose of opioid
naloxone
102
can be managed/txed w/ opioids
diarrhea
103
an overdose of codeine that significantly depresses breathing is tx w/
naloxone
104
makes sense to mix codeine w/ all except
hydrocodone/ (thyrocodone?)
105
all are side effects of nonsteroidal anti-inflammatory agents except
fluid loss
106
opioid agonist can produce all except
fluid retention
107
does not have a drug interaction w/ the nonsteroidal anti-inflammatory agents
codeine
108
acute overdose of acetaminophen hurts the
liver
109
if a person drinks an average of 2 beers daily, how many extra strength acetaminophen tablets can that person take in 1 day w/o going over maximum dose
4 tabs
110
pt takes aspirin (weak acid) and chews 2 antacids at same time, the absorption of the aspirin would be ____ the absorption that would have occurred if pt had not taken antacids
less than
111
if an adult has a fever, all of the following except _____ would reduce fever
codeine
112
allopurinol is used to manage pt with
gout
113
used to tx acute attack of gout
colchine
114
true allergy to aspirin occurs in about ____ of population
<1%
115
an advantage of the NSAIDS over opioids
nonaddictive
116
pt needs extraction. to ensure pt's bleeding time will be normal how long should you wait to preform procedure after taken aspirin
36 hrs
117
what to aspirin, acetaminophen, ibuprofen, and codeine have in common
analgesics
118
NSAIDS may reduce the antihypertensive effects of all except
calcium channel blocker
119
pt exhibits excessive sweating (not caused by excessive ambient temp or exercise) could be due to
stimulant of PANS
120
not caused by parasympatholytics
diarrhea
121
drug placed in FDA category B it means
animals struggle, no risk, not good habits
122
prostaglandins used therapeutically for
ulcers caused by NSAIDS
123
half life of drug is 12 hrs, what % of dosage would remain after 36hrs
12.5%
124
can produce lithium toxicity in pt taking lithium
naproxen
125
pharmacology is study of
drugs & medicine
126
the ___ regulates trade practices of drug companies and prohibits false advertising of foods, OTC drugs and cosmetics
FTC
127
not approved for efficacy and safety by FDA
vitamins
128
the ____ of a drug is a function of the amount of drug required to produce an effect
potency
129
a ____ has affinity for a receptor, combines w/ that receptor, and produces an effect
agonist
130
the ___ is the strongest bond and not rapidly reversible
covalent
131
a ___ is a dose-related reaction that is not part of the desired therapeutic effect
side-effect
132
a ____ is a genetically related abnormal drug response
idiosyncratic
133
a therapeutic index greater than ___ is needed to produce a therapeutically useful drug
10
134
codeine is a schedule ____ drug
II
135
the ___ includes name of drug, dose form, and amount
inscription
136
the ____ sets requirements for writing prescriptions for drugs frequently prescribed in dental office
control substitute act
137
action of acetylcholine is terminated by
hydrolysis
138
tx of an overdose of cholinesterase inhibitors includes ___ and ___
atropine
| pralidoxine
139
action of norepinephrine terminated by
reuptake into presynaptic nerve
140
dentist prescribed Percodan for pt after difficult extraction, pt arrives w/ family member somewhat confused and short of breath. low bp, slowed heart rate, nausea, pinpoint pupils
adverse reaction
141
antagonist pharmacological agent that should be used to tx pt in pervious question
naloxone
142
6 neurotransmitters
```
norepinephrine/epinephrine
dopamine
serotonin
acetylcholine
GABA
histamine
```
143
pulpitis
neuropathic chronic pain
144
post-herpetic neuralgia
neuropathic chronic pain
145
oral dysesthesia
nociceptive acute pain
146
maxillary sinusitis
nociceptive acute pain
147
migaines
neuropathic chronic pain
148
cancer
nociceptive acute pain
149
fibromyalgia
neuropathic chronic pain
150
exodontia
nociceptive acute pain
151
med for neuropathic pain
gabapentin & Neurontin
152
diaphoresis
perspiration
153
diflunisal
dolobid
154
dyspepsia
"upset stomach"; impaired gastric function
155
dysphoria
mood of general dissatisfaction, restlessness, anxiety, depression
156
eupepsia
good digestion
157
euphoria
feeling of well being
158
fentanyl
sublimaze
159
hydrocodone
in lorcet; Vicodin
160
hydromorphone
dilaudid
161
ibuprofen
Motrin
162
ketorolac
toradol
163
loperamide
Imodium
164
meperidine
Demerol
165
methadone
dolophine
166
naproxen
Naprosyn
167
naproxen sodium
anaprox
168
oxycodone
in Percocet; tylox
169
propoxyphene
in Darvocet-N 100
170
moa of aspirin may produce analgesia by inhibiting synthesis of ____ in the CNS
Prostaglandin
171
prolonged administration of large doses of aspirin results in
occult bleeding, anemia, or massive GI hemorrhage
172
ibuprofen is an NSAID that possesses ____&___ activities
analgesic, anti-inflammatory and antipyretic
173
indomethacin should be used cautiously in pt w/ ____,____, and ___or___ dz
epilepsy
parkinsonism
hepatic
renal
174
reye's syndrome may develop in children when ____ is used to tx fever from ____ infections
aspirin
| viral
175
chemical agent may be released in tissue injury during th process of inflammation
prostaglandin
176
prevent formation of the platelet-aggregating substance
aspirin
177
indicated for tx of pt w/ ductus arteriosus
indomethacin
178
salicylates s/b used w/ caution in pts on which med
anticoagulant
179
ibuprofen may be given to pts in all disorder/conditions except
dysmenorrhea
fever
rheumatoid arthritis
NOT peptic ulcer
180
the isoenzyme cox-2 is primarily assoc w/
inflammation
181
acetaminophen lacks
anti-inflammatory
182
like traditional NSAIDS, the cox-2 inhibitors cause all except
diarrhea
dyspepsia
abdominal pain
NOT osteoarthritis
183
adverse effects of acetaminophen are
rare
184
FDA labeled celecoxib for tx of
rheumatoid arthritis
185
acetaminophen
Tylenol
186
meloxicam
movera
187
celecoxib
Celebrex
188
pentazocine/naloxone
talwin
189
nalmefene HCI
revex
190
semisynthetic narcotics include
oxycodone
191
adverse effects of morphine include all except
dry mouth
constipation
biliary tract spasms
NOT hypertension
192
opioids or opiates can interact w/ alcohol and cause
respiratory depression
193
hydrocodone is classified as
schedule III
194
oxycodone is classified as schedule
II
195
opioids may be natural, synthetic or ____ morphine related substances
semisynthetic
196
the unripe capsules of Papaver somniferum contain approx. 9.5%
morphine
197
safety of naloxone during pregnancy or lactation is
not established
198
____ contraindicated in pt receiving opioid analgesics or in acute opioid withdrawal
naltrexone
199
phenothiazine's may interact w/ naltrexone and cause increased ___ and ____
somnolence
| lethargy
200
naloxone and naltrexone are
synthetic opioid antagonist
201
often used w/ aspirin or acetaminophen
oxycodone
202
often used during open-heart surgery
fentanyl
203
used for detoxification of opioid addiction
methadone
204
fewer undesirable effects than morphine
synthetic opioid analgesics
205
more addicting than codeine
hydrocodone
206
has caused fatal reactions within 14 days
meperidine
207
the principal moa for fentanyl are ___ and ___ but its action is more prompt and less than morphine
analgesia
| sedation
