Excitable Cells Flashcards

(78 cards)

1
Q

in what order is the body divided ?

A

cells - tissues - organ - organ system - human body

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2
Q

what is homeostasis ?

A

the ability of the body to maintain a relatively constant internal environment

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3
Q

what maintains homestasis ?

A

negative feedback loop

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4
Q

what are the two forms of negative feedback ?

A

local control or long-distance control

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5
Q

what are the two body fluid compartments ?

A

intracellular fluid (ICF) and estacellular fluid (ECF)

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6
Q

how much of the total body water is found in ICF ?

A

2/3

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7
Q

what do plasma membranes do ?

A
  • provides physical separation
  • regulates exchange of substances
  • communication with environment
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8
Q

what are the 5 plasma membrane components ?

A
  1. glycoprotein
  2. glycolipid
  3. cholesterol
  4. transmembrane protein
  5. peripheral protein
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9
Q

what does hydrophobic mean ?

A

water hating

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10
Q

what does hydrophilic mean ?

A

water loving

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11
Q

what size molecules are easier to move across gates ?

A

smaller

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12
Q

what is simple diffusion ?

A

from high concentration to low with zero assistance until meets equilibrium

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13
Q

factors of simple diffusion ?

A
  • hydrophobic (lipid soluble)
  • small
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14
Q

what substances participate in simple diffusion ?

A

oxygen, carbon dioxide and alcohol

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15
Q

Fick’s law of diffusion …

A

SA x Concentration Gradient / Membrane Thickness

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16
Q

3 passive forms of diffusion :

A
  • simple diffusion
  • channel-mediated diffusion
  • facilitated diffusion
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17
Q

in what case does diffusion require assistance ?

A

if it is hydrophilic and/or large

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18
Q

what does it mean to “require assistance” in passive diffusion ?

A

requires a transmembrane protein to help it across

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19
Q

examples of substances for channel-mediated diffusion :

A

ions and water

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20
Q

examples of substances for facilitated diffusion :

A

glucose and amino acids

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21
Q

what is channel mediated diffusion ?

A

transmembrane protein (open channel)

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22
Q

what is facilitated diffusion ?

A

transmembrane protein (open and closes channel)

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23
Q

what affects channel mediated diffusion ?

A
  • concentration gradient
  • number of channels
  • size
  • charge
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24
Q

what passive form of diffusion is selective and causes saturation ?

A

facilitated diffusion

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25
what form of diffusion moves opposite to their concentration gradient ?
active transport
26
what is an example of active transport ?
NaKATPase Pump
27
what is the sodium potassium ATPase Pump ?
- 3 sodiums out - 2 potassiums in - need energy (ATP) to do so
28
where is sodium usually the highest ?
outside the cell
29
how do really large molecules enter/exit the cell ?
endocytosis and exocytosis
30
what are the two forms of local communication ?
paracrine (close distance) and autocrine (itself)
31
what can directly connect two cells together ?
gap junctions
32
what are gap junctions connected by ?
connexons
33
what happens if gap junctions disappear ?
your heart will stop
34
how does water move in the body ?
aquaporins
35
what way is the concentration gradient moving during diffusion ?
high concentration to low concentration
36
what is osmosis ?
water diffusion down its concentration gradient
37
"what has a higher concentration of water"
do the number mM for each molecule present (ex. CaCl2 200mm = 200 + 200 + 200 = 600 while KCl 200mM = 200 + 200 = 400) ... side with more solutes = side it will move
38
what is tonicity ?
ability of a solution to cause osmosis across a cell
39
what is isotonic ?
the same (not changing)
40
what is hypertonic ?
more (bigger # and more solutes)
41
what is hypotonic ?
less (water moves into ICF, smaller number of solutes)
42
what is RMP affected by ?
permeability of membrane to various ions and concentration gradients of the ions
43
what is neutron RMP ?
-70mV
44
what element leak channels are present in cells ?
potassium
45
where is it more negative in a cell ?
inside
46
what are excitable cells ?
any cell that can be altered (cause impulse)
47
how do gated ion channels open ?
by a stimulus
48
what are the 3 gated channels types ?
- mechanically gated - chemically gated - voltage gated
49
what is mechanically gated ?
deforming the membrane
50
what is chemically-gated ?
a chemical binding the channel
51
what is another name for chemically-gated ?
ligand-gated
52
what is voltage-gated ?
voltage changes in the cell
53
what 7 features are on the neurons ?
- dendrites - soma - axon hillock - axon - myelin sheath - node of ranvier - axon terminal
54
what does axon terminal do ?
sends signals
55
what does the axon hillock do ?
connect axon and the soma
56
what is a myelin sheath ?
speeds up reaction
57
what is the input zone ?
dendrites and soma (graded potential)
58
what is the conducting zone ?
action potential travels here (axon)
59
what is the trigger zone ?
trigger action potential (depends on if threshold value is reached -55mV)
60
what is output zone ?
passes signal to next neutron by real leasing chemicals (synapse happening at axon terminal)
61
what is graded potential ?
depo / repo / hypo
62
what does depolarization mean ?
the cell becomes more positive than RMP
63
what does hyperpolarization mean ?
the cell becomes more negative than RMP
64
what does threshold mean ?
the minimum voltage to initiate action potential
65
where does Na move during depo ?
moves into the cell
66
where does Na move during repo ?
moves out of the cell (decreases in charge and becomes more negative)
67
what does amplitude mean ?
how high it goes
68
what is a graded potential ?
space that brings to threshold
69
during an AP what happens once hits +30mV ?
Na+ stops entering and K starts leaving neuron
70
what causes repolarization during AP to get back to RMP?
K+ leaving
71
what is the activation and inactivation gate at RMP ?
activation gate = closed inactivation gate = open
72
what is the activation and inactivation gate during depolarization ?
activation gate = open inactivation gate = closed
73
what is the activation and inactivation gate during repolarization ?
activation gate = open inactivation gate = closed
74
what influences speed of propagation ?
membrane resistance to ion leak (myelination) and axon diameter
75
what is happening during multiple scelorosis ?
multiple neutrons are hardening
76
what happens when the action potential reaches the axon terminal ?
chemical synapse
77
what is the synaptic cleft ?
the space between the presynaptic neutron and the postsynaptic neuron
78
what element opens channels at synapses ?
calcium