Extra Studying Flashcards

(67 cards)

1
Q

What is the model organism for colon cancer and other cancers?

A

E. coli

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2
Q

What is the model organism for cancer, and werner syndrome

A

S. cerevisiae

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3
Q

What is the model organism for disorders of the nervous system and cancer

A

D. melanogaster

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4
Q

What is the model organism for cardiovascular disease?

A

D. rerio

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5
Q

What is the model organism for Lesch-Nyhan disease, cystic fibrosis, fragile-X syndrome, and many other diseases?

A

M. musculus

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6
Q

Who:
- Created the Treatise on the seed
- Created the Pangenesis theory

A

Hippocrates

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7
Q

Who:
- Came up with the idea of “vital heat”

A

Aristotle

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8
Q

Who:
- Was the first to study genetic crosses in plants
- Provided evidence for blending theory of inheritance

A

Joseph Kolreuter

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9
Q

Who:
- Came up with the law of segregation
- Came up with the law of Independent Assortment

A

Gregor Mendel

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10
Q

Who:
- Created the pangenesis theory
- Wrote the origin of the species
- Came up with the theory of evolution
- Came up with descent with modification
-Discovered Natural Selection

A

Charles Darwin

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11
Q

Who:
- Came up with Homunculus

A

Paraculsus

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12
Q

Who:
- Came up with the Ex ovo omnia principle

A

William Harvey

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13
Q

Who:
- Came up with epigenesis

A

Casper Wolff

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14
Q

Who:
- Studied the theory of Natural selection separate from Darwin

A

Alfred Russell Wallace

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15
Q

Who:
- Verifies Mendel’s work

A

Hugo de Vries, Carl Correns, and Erich von Tschemak

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16
Q

Who:
- Responsible for the cell theory

A

Schleiden and Schwann

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17
Q

Who:
- Discovered sex chromosomes

A

Nettie Stevens and Edmund Wilson

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18
Q

Who:
- Responsible for the theory of sex-linked inheritance

A

Thomas Hunt Morgan

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19
Q

Who:
- Discovered the nature of the codon

A

Marshall Nirenberg and Heinrich Matthaei

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20
Q

Who:
- Identified DNA and nucleic acid

A

Friedrich Miecher

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21
Q

Who:
- Identified proteins

A

Jons Jacob Berzelius

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22
Q

Who:
- Created the Chargaff Rule

A

Erwin Chargaff

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23
Q

Who:
- Created the triplet code

A

Crick, Brenner, Barnett, and Watts-Tobin

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24
Q

Who:
- Was the first to observe cell division
- Discovered chromatin

A

Walter Flemming

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25
Who: - Came up withe the word "chromosome" - Saw chromosomal division - Observed off behavior in firebug chromatin
Hermann Henking
26
Who: - Created the chromosome theory of inheritance
Theodor Boveri and Walter Sutton
27
Who: - Developed culture techniques
Ross Granville Harrison
28
Who: - Was responsible for the immortal chicken heart culture
Alexis Carrel
29
Who: - Created the Hayflick limit
Leonard Hayflick
30
Who: - First identified telomeres
Hermann Muller
31
Who: - Identified telomere DNA sequence -GGGTTA
Elizabeth Blackburn and Jack Szostak
32
Who: - Discovered telomerase
Carol Greider and Elizabeth Blackburn
33
Traits that affect the appearance of the organism
Morphological traits
34
Traits that affect the function of the organism
Physiological traits
35
Traits whose expression is controlled by a single gene
Simple Mendelian Trait
36
Traits whose expression is influenced by the expression of multiple genes and/or environment
Multifactorial trait
37
Type of genetics that describes the movement of traits from parent to offspring
Transmission genetics
38
Type of genetics where changes in gene function that result from mutation
Molecular genetics
39
Type of genetics where genetic variation is shown in the evolution
Population genetics
40
Who: - Coined the word gene - Made the distinction between phenotype and genotype
Wilhelm Johannsen
41
Who: - Spectacle maker - Made the earliest microscope
Zacharias Janssen
42
What are crosses made in both ways called?
Reciprocal crosses
43
Mendel's three postulates are
1) Unit factors exist in pairs 2) Dominance/Recessiveness 3) Segregation
44
Purpose of in vitro cell culture
1) To study morphology, growth, and behavior of cells outside the body 2) To investigate cell toxicity in different environments
45
The Hayflick limit is also called
replicative senescence
46
What is the hayflick limit for human cells?
50
47
What are the three stages of cultured cells?
Phase 1) Primary culture, when cells multiply to cover the surface of the culture flask Phase 2) Cells are removed from one culture and transferred to another to grow and divide Phase 3) Cells stop dividing, but they may or may not die
48
what is the requirement for DNA replication?
Free 3' OH group
49
What are telomeres?
End caps that protect the chromosome
50
What are the components of telomerase?
Dyskerin, hTERT, hTERC
51
What is Dyskerin do?
It stabilizes telomerase complex
52
What is hTERT?
It is telomerase reverse trascriptase
53
What is hTERC?
telomerase RNA complex
54
What is necrosis and is it fatal?
Cell death in living tissue is caused by external factors. It is always detrimental to a patient and can be fatal
55
What is an example of coagulative necrosis?
Myocardial infarction and renal infarction
56
What is an example of liquefactive necrosis?
Infarct brain and abscess
57
What is an example of caseous necrosis?
Tuberculosis
58
What is an example of fat necrosis?
Acute pancreatitis and traumatic fat necrosis of the breast
59
What is an example of fibroid necrosis?
The accumulation of antigen-antibody complexes in organs and tissues
60
What is apoptosis
Programmed cell death
61
What mediates apoptosis?
Caspases
62
What protein blocks apoptosis?
Bcl2 homodimer
63
What protein promotes apoptosis?
BAX homodimer
64
What protein makes an inactive complex?
Bcl2-BAX
65
What are two examples of altered genes?
Proto-oncogenes and Tumor-suppressor genes
66
What is an example of a proto-oncogene?
ras genes (GTPases)
67
What is an example of a tumor-suppressor?
p53