extracellular matrix

Question 1

define basement membrane

Answer 1

basal lamina type of extracellular matrix; flexible, thin mats

Question 2

basement membrane location

Answer 2

surround muscle, peripheral nerves and fat cells; underlie epithelia

Question 3

basement membrane functions

Answer 3

highly selective filter (e.g. glomerulus)

Question 4

diabetic nephropathy

Answer 4

extracellular matrix accumulation at glomerulus, impinging on capillary and reducing renal function, leading to renal failure

Question 5

Alport syndrome

Answer 5

basement membrane abnormally split

Question 6

structure of basement membrane

Answer 6

caveolae, lipid bilayer, glycoprotein network (e.g. laminin), collagen fibrils (e.g. type IV), integrin (receptor)