1RCPCH TAS > Extras > Flashcards

Extras Flashcards

(19 cards)

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1
Q

What are some significant drug reactions with sodium valproate?

A

Phenytoin
Carbamazepine
Lamotrigine
Warfarin
Aspirin

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2
Q

What are some significant drug reactions for vigabatrin?

A

Limited as no hepatic metabolism
Caution in phenytoin, CNS depressents and antidepressants

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3
Q

What are the significant drug reactions of ethosuximide?

A

Valproate
Carbamazepine
Phenytoin
CNS depressants
Alcohol
Co-trimoxazole, linezolid, trimethoprim

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4
Q

What are the significant drug reactions associated with levetiracetam?

A

Carbamazepine
Methotrexate
OCPs

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5
Q

What are the significant drug interactions with phenobarbital?

A

Cytochrome P450 enzyme induced so reduces plasma conc. of many drugs
Valproate
OCPs
Warfarin

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6
Q

What are the significant drug reactions with phenytoin?

A

Warfarin
OCPs
Carbamazepine
Valproate

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7
Q

What are the significant drug interactions with adenosine?

A

Dipyridamole
Theophylline and xanthines
Carbamazepine
Caffeine

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8
Q

What are the significant drug interactions with amiodarone?

A

Warfarin
Digoxin
B-blockers
CCBs
Drugs that prolong the QT interval

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9
Q

What are the significant drug interactions associated with digoxin?

A

Diuretics
CCBs
Amiodarone
B-blockers
Macrolides

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10
Q

What are the significant drug interactions with propranolol?

A

CCBs
Insulin and oral hypoglyacemics
Other anti-arrythmics
Cimetidine
Alcohol
Anaesthetic agents

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11
Q

What are the significant drug interactions with flecainide?

A

B-blockers
Amiodarone
CCBs

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12
Q

What are the significant drug interactions for Flumazenil?

A

TCAs
Antiepileptics
Theophylline
Alcohol

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13
Q

In a child with hypoglycaemia and abnormal pH and bicarbonate with acidosis what could this indicate?

A

Adrenal failure or IEoM

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14
Q

In a child with hypoglycaemia and abnormal U&Es what could this indicate?

A

Dehydration
Adrenal insufficiency

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15
Q

In a child with hypoglycaemia and abnormal LFTs what could this indicate?

A

Primary liver disease
Sepsis
Glycogen storage disease
Galactosaemia
Fatty acid oxidation defects
Hereditary fructose intolerance

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16
Q

In a child with hypoglycaemia and raised ammonia what could this indicate?

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A

IEoM or hyperinsulinism

17
Q

In a child with hypoglycaemia and elevated free fatty acids and B-hydroxybutyrate what could this indicate?

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A

Appropriate lipolysis in response to hypoglycaamia

18
Q

In a child with hypoglycaemia and raised lactate what could this indicate?

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A

Sepsis
Metabolic liver disease
Glycogen storage disorders

19
Q

In a child with hypoglycaemia and low alanine what could this indicate?

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A

Accelerated starvation

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