FGT

Question 1

Means “disordered growth”

Answer 1

Dysplasia

Question 2

Characterized by a constellation of changes that include a loss in the uniformity of the individual cells as well as a loss in their architectural orientation

Answer 2

Dysplasia

Question 3

Dysplastic change that involve the full thickness of the epithelium, but the lesion does not penetrate the basement membrane

Answer 3

Carcinoma in situ

Question 4

Accounts for 60% of cases of carcinoma in situ

Answer 4

Human Papilloma virus 16

Question 5

Accounts for 10% of cases of carcinoma in situ

Answer 5

HPV 18

Question 6

HPV infects?

Answer 6

Immature basal cells or immature metaplastic squamous cells

Question 7

Prevents cell cycle arrest in carcinoma in situ, cervix

Answer 7

HPV E6 and E7 protein

Question 8

The most common histologic subtype, accounting for approx 80% of cases

Answer 8

Squamous cell carcinoma, cervix

Question 9

Risk factor of SCCA, cervix

Answer 9

HPV infection

Question 10

The most common invasive cancer of the FGT

Answer 10

Endometrial carcinoma

Question 11

What patters does endometrioid adenocarcinomas demonstrate?

Answer 11

Glandular growth patterns

Question 12

Histologic grade of endometrioid adenocarcinomas
1. Grade 1
2. Grade 2
3. Grade 3

Answer 12

1. Well differentiated - composed almost entirely of well formed glands
2. Moderately differentiated - shows well - formed glands, composed of solid sheets of cells, make up 50% or less of the tumor
3. Poorly differentiated - greater than 50% solid growth patterns

Question 13

Benign smooth muscle neoplasms that may occur singly, but more often are multiple

Answer 13

Leiomyoma

Question 14

Where can leiomyoma occur?

Answer 14

Within the myometrium (intramural)
Beneath the endometrium (submucosal)
Beneath the serosa (subserosal)

Question 15

are sharply circumscribed, discrete, round, firm, gray-white tumors varying in size from small, barely visible nodules to massive tumors that fill the pelvis

Answer 15

Leiomyomas

Question 16

Uncommon malignant neoplasm that arise from the myometrium or endometrial stromal precursor rather than leiomyoma

Answer 16

Leiomyosarcoma

Question 17

Peak age of leiomyosarcoma and where can it occur?

Answer 17

Peak age: 40-60yo
Occur: before and after menopause

Question 18

Metastasis of leiomyosarcoma

Answer 18

Hematogenous

Question 19

Distinction between leiomyoma and leiomyosarcoma

Answer 19

Nuclear atypia
Mitotic index (10 or more per 10 high power field)
Zonal necrosis

Question 20

Fallopian tube inflammations

Answer 20

Suppurative salpingitis and tuberculous salpingitis

Question 21

Kinds of fallopian tube cysts

Answer 21

Paratubal cysts and hydatids of morgagni

Question 22

Smaller fallopian tube cyst

Answer 22

Paratubal cysts

Question 23

Larger fallopian tube cyst

Answer 23

Hydatids of morgagni

Question 24

Difference in cystic follicles and follicular cysts

Answer 24

Size

Question 25

Size of cystic follicle

Answer 25

2mm with fluid

Question 26

Size of follicular cyst

Answer 26

More than 2mm in size

Question 27

Central morphologic abnormality of PCOS

Answer 27

Numerous cystic follicles or follicle cyst

Question 28

Ovarian tumors that ( -80%) occur mostly in young women between 2- and 45 years of age

Answer 28

Benign tumors

Question 29

Ovarian tumors - ( tumors of indeterminate malignancy) occur at slightly older ages

Answer 29

Borderline tumors

Question 30

Ovarian tumors that are more common in women between 45 and 65 years of age

Answer 30

Malignant tumors

Question 31

Most primary ovarian neoplasms arise from

Answer 31

Mullerian epithelium

Question 32

3 histologic types of epithelial differentiation

Answer 32

Serous Mucinous Endometrioid

Question 33

WHO classifications of ovarian neoplasms benign: malignant:

Answer 33

Benign - cystadenoma - cystadenofibroma - adenofibroma Malignant - cystadenocarcinoma - adenocarcinoma

Question 34

Most common malignant ovarian tumor

Answer 34

Serous tumor

Question 35

Percentage of serous tumor if either benign or malignant

Answer 35

70% are benign/borderline 30% are malignant

Question 36

Risk factor or serous tumor

Answer 36

BRCA1 and 2 mutations

Question 37

Multi cystic lesion in which papillary epithelium is contained within fibrous walled cysts Mass projecting from the ovarian surface

Answer 37

Serous tumor

Question 38

Other name for “medusa head” configuration

Answer 38

Micro papillary pattern

Question 39

Middle adult life and are rare before puberty and after menopause Vast majority are benign or borderline tumors Primary ovarian mucinous carcinomas: uncommon

Answer 39

Mucinous tumors

Question 40

3 categories of teratoma

Answer 40

Mature teratoma Immature teratoma Monodermal teratoma

Question 41

Mature (benign) teratomas are often referred to as?

Answer 41

Dermoid cyst

Question 42

Component tissue resemble embryonal and immature fetal tissue

Answer 42

Immature malignant teratoma

Question 43

2 Metastatic tumor of the ovary

Answer 43

Mullerian origin Extra-mullerian origin

Question 44

Metastatic tumor of the ovary Uterus,fallopian tube, contralateral ovary, or pelvic peritoneum

Answer 44

Mullerian origin

Question 45

Metastatic tumors of the ovary Carcinomas of the breast and GIT Pseudomyxoma peritonei

Answer 45

Extra-mullerian

Question 46

Metastatic tumor of the ovary has what kind of appearance?

Answer 46

“Signet-ring” appearance

Question 47

Most common site of ectopic pregnancy

Answer 47

Extrauterine fallopian tube

Question 48

Abnormalities of placental implantation

Answer 48

Accreta Increta Percreta

Question 49

Gestational throphoblastic disorder that has 2.5% risk of choriocarcinoma

Answer 49

Complete mole

Question 50

Gestational throphoblastic disorder that has no rish for choriocarcinoma

Answer 50

Partial mole

Question 51

A malignant neoplasm of trophoblastic cells derived from a previously normal or abnormal pregnancy

Answer 51

Gestational choriocarcinoma