Final exam old stuff

Question 1

Reading graph: Max efficacy

Answer 1

The high point of the graph

Question 2

Reading graph: Potency

Answer 2

The one more to the left

Question 3

Quantal curve vs dose response

Answer 3

• “ing” y-axis is a quantal curve

Question 4

Therapeutic Index

Answer 4

TD50 / ED50

-higher number means more safe

Question 5

NSAIDs vs acetaminophen

Answer 5

NSAIDs block COX (1 = housekeep, 2= inflam process)

Acetaminophen: for pain and fever only

Question 6

Acetaminophen

Answer 6

• for pain and fever only
• NOT anti-inflammatory
• only inhibits prostaglandins in CNS

Question 7

Receptors in heart

Answer 7

Beta 1

Question 8

Receptors in lungs

Answer 8

Beta 2

Question 9

2 net effects of asthma

Answer 9

-inflammations and bronchoconstriction

Question 10

2 ways to treat asthma

Answer 10

• use anti-inflammatory agents

- use bronchodilators

Question 11

Glucocorticoids

Answer 11

• involved in carb metabolism

- regulated by ACTH

Question 12

Mineralcorticoids

Answer 12

• salt and water balance

- renin-angiotensin regulation

Question 13

MOA of antidepressants

Answer 13

• inc NT release
• over stim postsynaptic receptors
• = compensatory dec regulation and dec sensitivity

Question 14

Barbiturates vs BDZs

Answer 14

Barbiturates = duration of channel opening 
BDZs = freq of opening

channel = GABA!!

Question 15

What is the side effect of muscle relaxers

Answer 15

SEDATION!!!!!!

Question 16

What are the 4 EPS effects?

Answer 16

• Dystonia (spasms)
• parkinsonism (like the disease)
• Akathisia (restless movement)
• Tardive dyskinesia (oral, facial movements)

Question 17

Alzheimer’s cause

Answer 17

-dec cholinergic neurons

Question 18

ALS cause

Answer 18

-loss of peripheral neurons

Question 19

Schizophrenia

Answer 19

• too much dopamine

Question 20

Parkinson’s

Answer 20

• too little dopamine