Final notes

Question 1

Cutoff for anion gap

Answer 1

Greater than 12

Question 2

Affect of lowering threshold

Answer 2

Increase NPV

Increase seNsitivity

Question 3

When would you use filgrastim sargramostim?

Answer 3

Both are used to recover bone marrow, but Filgrastim is G-CSF, and Sargramostim is GM-CSF, so use sargramostim if you need to recover monocytes/macrophages.

Question 4

non-alcoholic fatty liver disease pathophys

Answer 4

metabolic syndrome (insulin resistance); obesity –> fatty infiltration of hepatocytes –> cellular “ballooning” and eventual necrosis. NOT ASSOCIATED WITH ALCOHOL USE, but can lead to cirrhosis and HCC.

Question 5

inverse agonist

Answer 5

Drug that binds to the same receptor but induces the opposite response.