Function
DNA Polymerase I
Function
DNA Polymerase III
Synthesizes most of the DNA during DNA replication
Primase
RNA polymerase that creates primers
- Provides 3’ -OH end for DNA polymerase
Function
Helicase
“Unwinds” DNA
- binds to one strand in 5’-3’
Function
Topoisomerase
Cuts and reseals DNA to relive supercoiling
SSB
Genetics
Single Strand Binding Protiens
- Stabilizes the complex, prevents reannealing of DNA strands
Function
Beta-Clamp
Keeps DNA Pol. attatched to DNA
Function
Ligase
“Glues” DNA together
Telomerase
Enzyme that adds nucleotides to telomeres
Active in:
- Germ cells
- Cancer cells
- Immune cells
- Embrionic development
Cohesin
Holds sister chromatids together
SRY gene
The “maleness gene”
Directs the male development of the bipotential gonad
- If present –> Male
- If absent –> Female
white gene in fruitflies
X-linked recessive gene
- Causes white eyes
Function
Xist
Causes random X chromosome inactivation
Reverse Transciptase
Capable of synthesizing DNA (complementary DNA, or cDNA) from an RNA template, essentially reversing the normal flow of genetic information (RNA to protein)
Genomics
The study of ENTIRE GENOMES
Transcriptomics
The cataloguing of all RNAs in a sample
Reaction Norm
The effect of the environment on phenotype
Morph
A rare but recuring mutation in a population
- melanistic cats
- spirit bear
NOT A SUBSPECIES
Genome
The complete set of genetic instructions of an organism
Kinetochore
Binds centromeres together
- Acts as a docking platform for mitotic spindle
Centromere
Specialized area of a chromosome ment for mitotic spindles to attatch to
Microtuble organizing centers (MTOCs)
Centrosomes in animals
- Directs DNA seperation with spindle fibers
Trait vs Character
Character = Catagory
Trait = Varients in the catagory
Nondisjunction
Failure of homologus chromosomes to seperate and mover to opposite poles