1
Q
What substance is used to measure effective renal plasma flow?
A
para-aminohippuric acid (PAH) clearance; PAH both filtered & actively secreted in proximal tubule
2
Q
How can one calculate renal blood flow from effective renal plasma flow?
A
RBF = RPF (1-Hct)
3
Q
Define filtration fraction. What is the normal value for FF?
A
GFR/RPF; normal = 20%
4
Q
What is the deficiency in Hartnup disease?
A
Deficiency of neutral amino acid transporters in proximal renal tubular cells & on enterocytes –> neutral aminoaciduria
5
Q
What is the inheritance pattern of Hartnup disease?
A
Autosomal recessive
6
Q
What type of symptoms does Hartnup disease result in?
A
Pellagra-like
Renal & Urinary
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