What is the purpose of a right shift of the oxyhemoglobin dissociation curve?
Increase delivery of O2 to the tissues
What causes a right shift of the oxyhemoglobin curve?
Acidosis: reduced pH, increased [H+]
Increased CO2
Increased 2,3-DPG
Increased temperature
What is the purpose of a left shift of the oxyhemoglobin dissociation curve?
Decrease delivery of O2 to the tissues
What causes a left shift of the oxyhemoglobin curve?
Alkalosis: increased pH, decreased [H+] Decreased CO2 Decreased 2,3-DPG Decreased temperature HbF, methaemaglobin, carboxyhaemaglobin