Fitz - Random

Question 1

DPD

Answer 1

5-FU liver metabolism, allelic variation, hereditary deficiency

Question 2

Patient on chemo…experiences GI intolerance, recurrent infections, neurologic deficits, hair loss, stumbling

Answer 2

5-FU, DPD deficiency/decreased expression, toxicities

Question 3

5-FU co-administration w/ what for better efficacy?

Answer 3

MTX, Leucovorin

Question 4

Multi-drug resistance

Answer 4

Microtubule drugs (Vinca alkaloids, Taxanes)